GA4GH: International policies and standards for data sharing across genomic research and healthcare.
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Authors
Rehm, Heidi L
Page, Angela JH
Smith, Lindsay
Adams, Jeremy B
Alterovitz, Gil
Babb, Lawrence J
Barkley, Maxmillian P
Baudis, Michael
Beauvais, Michael JS
Beck, Tim
Beckmann, Jacques S
Beltran, Sergi
Bernick, David
Bernier, Alexander
Bonfield, James K
Boughtwood, Tiffany F
Bourque, Guillaume
Bowers, Sarion R
Brookes, Anthony J
Brudno, Michael
Brush, Matthew H
Bujold, David
Burdett, Tony
Buske, Orion J
Cabili, Moran N
Cameron, Daniel L
Carroll, Robert J
Casas-Silva, Esmeralda
Chakravarty, Debyani
Chaudhari, Bimal P
Chen, Shu Hui
Cherry, J Michael
Chung, Justina
Cline, Melissa
Clissold, Hayley L
Cook-Deegan, Robert M
Courtot, Mélanie
Cunningham, Fiona
Cupak, Miro
Davies, Robert M
Denisko, Danielle
Doerr, Megan J
Dolman, Lena I
Dove, Edward S
Dursi, L Jonathan
Dyke, Stephanie OM
Eddy, James A
Eilbeck, Karen
Ellrott, Kyle P
Fairley, Susan
Fakhro, Khalid A
Firth, Helen V
Fitzsimons, Michael S
Fiume, Marc
Flicek, Paul
Fore, Ian M
Freeberg, Mallory A
Freimuth, Robert R
Fromont, Lauren A
Fuerth, Jonathan
Gaff, Clara L
Gan, Weiniu
Ghanaim, Elena M
Glazer, David
Green, Robert C
Griffith, Malachi
Griffith, Obi L
Grossman, Robert L
Groza, Tudor
Auvil, Jaime M Guidry
Guigó, Roderic
Gupta, Dipayan
Haendel, Melissa A
Hamosh, Ada
Hansen, David P
Hart, Reece K
Hartley, Dean Mitchell
Haussler, David
Hendricks-Sturrup, Rachele M
Ho, Calvin WL
Hobb, Ashley E
Hoffman, Michael M
Hofmann, Oliver M
Holub, Petr
Hsu, Jacob Shujui
Hubaux, Jean-Pierre
Hunt, Sarah E
Husami, Ammar
Jacobsen, Julius O
Jamuar, Saumya S
Janes, Elizabeth L
Jeanson, Francis
Jené, Aina
Johns, Amber L
Joly, Yann
Jones, Steven JM
Kanitz, Alexander
Kato, Kazuto
Keane, Thomas M
Kekesi-Lafrance, Kristina
Kelleher, Jerome
Kerry, Giselle
Khor, Seik-Soon
Knoppers, Bartha M
Konopko, Melissa A
Kosaki, Kenjiro
Kuba, Martin
Lawson, Jonathan
Leinonen, Rasko
Li, Stephanie
Lin, Michael F
Linden, Mikael
Liu, Xianglin
Udara Liyanage, Isuru
Lopez, Javier
Lucassen, Anneke M
Lukowski, Michael
Mann, Alice L
Marshall, John
Mattioni, Michele
Metke-Jimenez, Alejandro
Milne, Richard J
Molnár-Gábor, Fruzsina
Mulder, Nicola
Munoz-Torres, Monica C
Nag, Rishi
Nakagawa, Hidewaki
Nasir, Jamal
Navarro, Arcadi
Nelson, Tristan H
Niewielska, Ania
Nisselle, Amy
Niu, Jeffrey
Nyrönen, Tommi H
O'Connor, Brian D
Oesterle, Sabine
Ogishima, Soichi
Wang, Vivian Ota
Paglione, Laura AD
Palumbo, Emilio
Parkinson, Helen E
Philippakis, Anthony A
Pizarro, Angel D
Prlic, Andreas
Rambla, Jordi
Rendon, Augusto
Rider, Renee A
Robinson, Peter N
Rodarmer, Kurt W
Rodriguez, Laura Lyman
Rubin, Alan F
Rueda, Manuel
Rushton, Gregory A
Ryan, Rosalyn S
Saunders, Gary I
Schuilenburg, Helen
Schwede, Torsten
Scollen, Serena
Senf, Alexander
Sheffield, Nathan C
Skantharajah, Neerjah
Smith, Albert V
Sofia, Heidi J
Spalding, Dylan
Spurdle, Amanda B
Stark, Zornitza
Stein, Lincoln D
Suematsu, Makoto
Tan, Patrick
Tedds, Jonathan A
Thomson, Alastair A
Thorogood, Adrian
Tickle, Timothy L
Tokunaga, Katsushi
Törnroos, Juha
Torrents, David
Upchurch, Sean
Valencia, Alfonso
Guimera, Roman Valls
Vamathevan, Jessica
Varma, Susheel
Vears, Danya F
Viner, Coby
Voisin, Craig
Wagner, Alex H
Wallace, Susan E
Walsh, Brian P
Williams, Marc S
Winkler, Eva C
Wold, Barbara J
Wood, Grant M
Woolley, J Patrick
Yamasaki, Chisato
Yates, Andrew D
Yung, Christina K
Zass, Lyndon J
Zaytseva, Ksenia
Zhang, Junjun
Goodhand, Peter
North, Kathryn
Birney, Ewan
Publication Date
2021-11-10Journal Title
Cell Genom
ISSN
2666-979X
Publisher
Elsevier BV
Volume
1
Issue
2
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Rehm, H. L., Page, A. J., Smith, L., Adams, J. B., Alterovitz, G., Babb, L. J., Barkley, M. P., et al. (2021). GA4GH: International policies and standards for data sharing across genomic research and healthcare.. Cell Genom, 1 (2) https://doi.org/10.1016/j.xgen.2021.100029
Abstract
The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical and genomic data through both harmonized data aggregation and federated approaches. The decreasing cost of genomic sequencing (along with other genome-wide molecular assays) and increasing evidence of its clinical utility will soon drive the generation of sequence data from tens of millions of humans, with increasing levels of diversity. In this perspective, we present the GA4GH strategies for addressing the major challenges of this data revolution. We describe the GA4GH organization, which is fueled by the development efforts of eight Work Streams and informed by the needs of 24 Driver Projects and other key stakeholders. We present the GA4GH suite of secure, interoperable technical standards and policy frameworks and review the current status of standards, their relevance to key domains of research and clinical care, and future plans of GA4GH. Broad international participation in building, adopting, and deploying GA4GH standards and frameworks will catalyze an unprecedented effort in data sharing that will be critical to advancing genomic medicine and ensuring that all populations can access its benefits.
Sponsorship
European Commission Horizon 2020 (H2020) Research Infrastructures (RI) (824087)
Identifiers
PMC8774288, 35072136
External DOI: https://doi.org/10.1016/j.xgen.2021.100029
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334447
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