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dc.contributor.authorWatson, Andrew J
dc.contributor.authorGiordano, Annalisa
dc.contributor.authorSuckling, John
dc.contributor.authorBarnes, Thomas RE
dc.contributor.authorHusain, Nusrat
dc.contributor.authorJones, Peter B
dc.contributor.authorKrynicki, Carl R
dc.contributor.authorLawrie, Stephen M
dc.contributor.authorLewis, Shôn
dc.contributor.authorNikkheslat, Naghmeh
dc.contributor.authorPariante, Carmine M
dc.contributor.authorUpthegrove, Rachel
dc.contributor.authorDeakin, Bill
dc.contributor.authorDazzan, Paola
dc.contributor.authorJoyce, Eileen M
dc.date.accessioned2022-03-01T00:30:39Z
dc.date.available2022-03-01T00:30:39Z
dc.date.issued2022-02-18
dc.identifier.issn0033-2917
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334526
dc.description.abstractBACKGROUND: Evidence suggests that cognitive subtypes exist in schizophrenia that may reflect different neurobiological trajectories. We aimed to identify whether IQ-derived cognitive subtypes are present in early-phase schizophrenia-spectrum disorder and examine their relationship with brain structure and markers of neuroinflammation. METHOD: 161 patients with recent-onset schizophrenia spectrum disorder (<5 years) were recruited. Estimated premorbid and current IQ were calculated using the Wechsler Test of Adult Reading and a 4-subtest WAIS-III. Cognitive subtypes were identified with k-means clustering. Freesurfer was used to analyse 3.0 T MRI. Blood samples were analysed for hs-CRP, IL-1RA, IL-6 and TNF-α. RESULTS: Three subtypes were identified indicating preserved (PIQ), deteriorated (DIQ) and compromised (CIQ) IQ. Absolute total brain volume was significantly smaller in CIQ compared to PIQ and DIQ, and intracranial volume was smaller in CIQ than PIQ (F(2, 124) = 6.407, p = 0.002) indicative of premorbid smaller brain size in the CIQ group. CIQ had higher levels of hs-CRP than PIQ (F(2, 131) = 5.01, p = 0.008). PIQ showed differentially impaired processing speed and verbal learning compared to IQ-matched healthy controls. CONCLUSIONS: The findings add validity of a neurodevelopmental subtype of schizophrenia identified by comparing estimated premorbid and current IQ and characterised by smaller premorbid brain volume and higher measures of low-grade inflammation (CRP).
dc.format.mediumPrint-Electronic
dc.publisherCambridge University Press (CUP)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCognition
dc.subjectinflammation
dc.subjectneuroimaging
dc.subjectpsychosis
dc.subjectschizophrenia-spectrum disorder
dc.subjectsubtypes
dc.titleCognitive function in early-phase schizophrenia-spectrum disorder: IQ subtypes, brain volume and immune markers.
dc.typeArticle
dc.publisher.departmentDepartment of Psychiatry
dc.date.updated2022-02-28T13:43:34Z
prism.endingPage10
prism.publicationDate2022
prism.publicationNamePsychol Med
prism.startingPage1
dc.identifier.doi10.17863/CAM.81944
dcterms.dateAccepted2021-11-03
rioxxterms.versionofrecord10.1017/S0033291721004815
rioxxterms.versionAM
dc.contributor.orcidWatson, Andrew J [0000-0002-1198-571X]
dc.identifier.eissn1469-8978
rioxxterms.typeJournal Article/Review
pubs.funder-project-idNational Institute for Health Research (NIHR) via Comprehensive Local Research Network (CLRN) (10411)
cam.issuedOnline2022-02-18
cam.orpheus.success2022-02-28 - Embargo set during processing via Fast-track
cam.depositDate2022-02-28
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2022-08-18


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International