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dc.contributor.authorCalejman, C Martinez
dc.contributor.authorDoxsey, WG
dc.contributor.authorFazakerley, Daniel
dc.contributor.authorGuertin, DA
dc.date.accessioned2022-03-02T00:30:42Z
dc.date.available2022-03-02T00:30:42Z
dc.date.issued2022-06
dc.identifier.issn0968-0004
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334573
dc.description.abstractInsulin stimulates glucose uptake into adipocytes via mTORC2/AKT signaling and GLUT4 translocation and directs glucose carbons into glycolysis, glycerol for TAG synthesis, and de novo lipogenesis. Adipocyte insulin resistance is an early indicator of type 2 diabetes in obesity, a worldwide health crisis. Thus, understanding the interplay between insulin signaling and central carbon metabolism pathways that maintains adipocyte function, blood glucose levels, and metabolic homeostasis is critical. While classically viewed through the lens of individual enzyme-substrate interactions, advances in mass spectrometry are beginning to illuminate adipocyte signaling and metabolic networks on an unprecedented scale, yet this is just the tip of the iceberg. Here, we review how 'omics approaches help to elucidate adipocyte insulin action in cellular time and space.
dc.description.sponsorshipNone from UK. NIH in USA and ANPCyT and Universidad de Buenos Aires in Argentina
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleIntegrating adipocyte insulin signaling and metabolism in the multi-omics era.
dc.typeArticle
dc.publisher.departmentDepartment of Clinical Biochemistry
dc.date.updated2022-03-01T09:52:19Z
prism.publicationNameTrends Biochem Sci
dc.identifier.doi10.17863/CAM.81992
dcterms.dateAccepted2022-02-21
rioxxterms.versionofrecord10.1016/j.tibs.2022.02.009
rioxxterms.versionAM
dc.contributor.orcidFazakerley, Daniel [0000-0001-8241-2903]
dc.identifier.eissn1362-4326
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/S007091/1)
cam.orpheus.successWed Mar 23 10:26:38 GMT 2022 - Embargo updated
cam.depositDate2022-03-01
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-03-31


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International