Show simple item record

dc.contributor.authorJarzebowski, Przemyslaw
dc.date.accessioned2022-03-03T12:00:00Z
dc.date.available2022-03-03T12:00:00Z
dc.date.submitted2021-12-01
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334631
dc.description.abstractThe memory of where to find food can be crucial for an animal’s survival. Encoding and recall of these spatial memories involves the hippocampus, but whether and how hippocampal activity integrates memories of spatial relationships and locations is poorly understood. This thesis investigates how hippocampal activity facilitates the encoding of reward memories and how this encoding shapes hippocampal activity during memory recall in mice learning reward locations. Encoding of memory happens in stages that depend on the hippocampal state. The thesis interrogated how two different hippocampal states, one during movement and the other during reward consumption, are affected by acetylcholine – a neuromodulator released predominantly during movement and exploration. The findings highlight how acetylcholine modulates hippocampal state and how, when experimentally altered, it can impede memory encoding. Hippocampal activity facilitates navigation towards the learned reward locations. Individual neurons fire at specific locations of the environment, and, collectively, they cover the environment forming its cognitive map. To answer how the hippocampal activity could encode a memory of reward location, the thesis investigated how these spatial representations and the population activity change after learning. I found that the reward memory shapes the activity in the dorsal CA1 of the hippocampus by modulating its overall population activity and in the intermediate CA1 by modulating the activity of a reward-specific cell population. Together, these results suggest how hippocampal activity could facilitate encoding and recall of memory for reward locations.
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjecthippocampus
dc.subjectmemory
dc.subjectacetylcholine
dc.subjectCA1
dc.subjectreward
dc.subjectnavigation
dc.titleEncoding and recall of memory for reward location in the mouse hippocampus
dc.typeThesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (PhD)
dc.publisher.institutionUniversity of Cambridge
dc.date.updated2022-03-02T16:05:49Z
dc.identifier.doi10.17863/CAM.82050
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.typeThesis
dc.publisher.collegeSt Edmunds
pubs.funder-project-idBBSRC (1943824)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (1943824)
cam.supervisorPaulsen, Ole
cam.depositDate2022-03-02
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)