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dc.contributor.authorLiu, Xiangjun
dc.contributor.authorJin, Shanzhao
dc.contributor.authorHu, Simeng
dc.contributor.authorLi, Ruoyan
dc.contributor.authorPan, Haihao
dc.contributor.authorLiu, Yi
dc.contributor.authorLai, Pan
dc.contributor.authorXu, Deshu
dc.contributor.authorSun, Jingru
dc.contributor.authorLiu, Ziyang
dc.contributor.authorGao, Yumei
dc.contributor.authorZhao, Yifan
dc.contributor.authorLiu, Fengjie
dc.contributor.authorXiao, Yu
dc.contributor.authorLi, Yingyi
dc.contributor.authorWen, Yujie
dc.contributor.authorChen, Zhuojing
dc.contributor.authorXu, Bufang
dc.contributor.authorLin, Yuchieh
dc.contributor.authorRan, Menglong
dc.contributor.authorLi, Qianxi
dc.contributor.authorYang, Shuxia
dc.contributor.authorLi, Hang
dc.contributor.authorTu, Ping
dc.contributor.authorHaniffa, Muzlifah
dc.contributor.authorTeichmann, Sarah
dc.contributor.authorBai, Fan
dc.contributor.authorWang, Yang
dc.date.accessioned2022-03-03T16:00:56Z
dc.date.available2022-03-03T16:00:56Z
dc.date.issued2022-03-03
dc.date.submitted2021-07-24
dc.identifier.issn2041-1723
dc.identifier.others41467-022-28799-3
dc.identifier.other28799
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334643
dc.descriptionFunder: National Nature Science Foundation of China 81922058 National Science and Technology Major Project 2019YFC1315702 Guangdong Province Key Research and Development Program 2019B020226002 National Youth Top-Notch Talent Support Program 283812 Peking University Clinical Medicine plus X Youth Project PKU2019LCXQ012
dc.description.abstractCutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin lymphoma distinguished by the presence of clonal malignant T cells. The heterogeneity of malignant T cells and the complex tumor microenvironment remain poorly characterized. With single-cell RNA analysis and bulk whole-exome sequencing on 19 skin lesions from 15 CTCL patients, we decipher the intra-tumor and inter-lesion diversity of CTCL patients and propose a multi-step tumor evolution model. We further establish a subtyping scheme based on the molecular features of malignant T cells and their pro-tumorigenic microenvironments: the TCyEM group, demonstrating a cytotoxic effector memory T cell phenotype, shows more M2 macrophages infiltration, while the TCM group, featured by a central memory T cell phenotype and adverse patient outcome, is infiltrated by highly exhausted CD8+ reactive T cells, B cells and Tregs with suppressive activities. Our results establish a solid basis for understanding the nature of CTCL and pave the way for future precision medicine for CTCL patients.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectArticle
dc.subject/631/250/580
dc.subject/692/4028/67/1813
dc.subject/692/4028/67/2329
dc.subject/692/420/755
dc.subject/631/67/1990/291/1621/1916
dc.subject/49/91
dc.subjectarticle
dc.titleSingle-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma.
dc.typeArticle
dc.date.updated2022-03-03T16:00:55Z
prism.issueIdentifier1
prism.publicationNameNat Commun
prism.volume13
dc.identifier.doi10.17863/CAM.82061
dcterms.dateAccepted2022-02-14
rioxxterms.versionofrecord10.1038/s41467-022-28799-3
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidJin, Shanzhao [0000-0003-3939-4978]
dc.contributor.orcidLiu, Yi [0000-0003-2990-5738]
dc.contributor.orcidLiu, Ziyang [0000-0002-3067-9523]
dc.contributor.orcidZhao, Yifan [0000-0001-9303-4215]
dc.contributor.orcidHaniffa, Muzlifah [0000-0002-3927-2084]
dc.contributor.orcidTeichmann, Sarah [0000-0002-6294-6366]
dc.contributor.orcidBai, Fan [0000-0001-6119-8936]
dc.contributor.orcidWang, Yang [0000-0001-7805-2861]
dc.identifier.eissn2041-1723
cam.issuedOnline2022-03-03


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