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dc.contributor.authorSewell, Gavin
dc.contributor.authorKaser, Arthur
dc.date.accessioned2022-03-04T00:30:19Z
dc.date.available2022-03-04T00:30:19Z
dc.identifier.issn1873-9946
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334652
dc.description.abstractThe IL-23 cytokine, derived predominantly from macrophages and dendritic cells in response to microbial stimulation, has emerged as a critical promoter of chronic intestinal inflammation. Genome-wide association studies linking variants in IL-23R to disease protection, bolstered by experimental evidence from colitis models, and the successful application of therapies against the IL-12/IL-23 shared p40 subunit in the treatment of inflammatory bowel disease all provide compelling evidence of a crucial role for IL-23 in disease pathogenesis. Moreover, targeting the p19 subunit specific for IL-23 has shown considerable promise in recent phase 2 studies in inflammatory bowel disease. The relative importance of the diverse immunological pathways downstream of IL-23 in propagating mucosal inflammation in the gut however remains contentious. Here we review current understanding of IL-23 biology and explore its pleiotropic effects on T cells, innate lymphoid, myeloid and intestinal epithelial cells in the context of inflammatory bowel disease pathogenesis. We furthermore discuss these pathways in the light of recent evidence from clinical trials and indicate emerging targets amenable to therapeutic intervention and translation into clinical practice.
dc.description.sponsorshipAcademy of Medical Sciences
dc.publisherOxford University Press (OUP)
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleInterleukin-23 in IBD pathogenesis and implications for therapeutic intervention
dc.typeArticle
dc.publisher.departmentDepartment of Medicine
dc.date.updated2022-03-02T15:57:58Z
prism.publicationNameJournal of Crohn's and Colitis
dc.identifier.doi10.17863/CAM.82070
dcterms.dateAccepted2022-02-19
rioxxterms.versionAM
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (106260/Z/14/Z)
pubs.funder-project-idAcademy of Medical Sciences (SGL022\1008)
pubs.funder-project-idWellcome Trust (222497/Z/21/Z)
cam.orpheus.counter26*
cam.depositDate2022-03-02
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2025-03-03


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