The evolution of mendelian randomization for investigating drug effects.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Abstract
Dipender Gill and Stephen Burgess discuss the accompanying study by James Yarmolinsky and colleagues investigating the associations between genetically-proxied inhibition of antihypertensive drug targets and risk of common cancer subtypes using Mendelian randomization.
Description
Keywords
Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Blood Pressure, Colorectal Neoplasms, Genetic Variation, Genome-Wide Association Study, Humans, Mendelian Randomization Analysis, Risk Factors
Journal Title
PLoS Med
Conference Name
Journal ISSN
1549-1277
1549-1676
1549-1676
Volume Title
19
Publisher
Public Library of Science (PLoS)
Publisher DOI
Sponsorship
Wellcome Trust (204623/Z/16/Z)
Medical Research Council (MC_UU_00002/7)
British Heart Foundation (None)
British Heart Foundation (RG/18/13/33946)
Medical Research Council (MC_UU_00002/7)
British Heart Foundation (None)
British Heart Foundation (RG/18/13/33946)