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dc.contributor.authorChamberlain, Samuel G
dc.contributor.authorOwen, Darerca
dc.contributor.authorMott, Helen
dc.date.accessioned2022-03-12T00:30:23Z
dc.date.available2022-03-12T00:30:23Z
dc.date.issued2022-06
dc.identifier.issn0265-9247
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334909
dc.description.abstractBoth RalA and RalB interact with the ubiquitous calcium sensor, calmodulin (CaM). New structural and biophysical characterisation of these interactions strongly suggests that, in the native membrane-associated state, only RalA can be extracted from the membrane by CaM and this non-canonical interaction could underpin the divergent signalling roles of these closely related GTPases. The isoform specificity for RalA exhibited by CaM is hypothesised to contribute to the disparate signalling roles of RalA and RalB in mitochondrial dynamics. This would lead to CaM shuttling RalA to the mitochondrial membrane but leaving RalB localisation unperturbed, and in doing so triggering mitochondrial fission pathways rather than mitophagy.
dc.publisherWiley
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleMembrane extraction by calmodulin underpins the disparate signalling of RalA and RalB.
dc.typeArticle
dc.publisher.departmentDepartment of Biochemistry
dc.date.updated2022-03-10T19:04:42Z
prism.publicationNameBioessays
dc.identifier.doi10.17863/CAM.82347
dcterms.dateAccepted2022-03-10
rioxxterms.versionofrecord10.1002/bies.202200011
rioxxterms.versionAM
dc.contributor.orcidOwen, Darerca [0000-0003-0978-5425]
dc.contributor.orcidMott, Helen [0000-0002-7890-7097]
dc.identifier.eissn1521-1878
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/E013228/1)
pubs.funder-project-idBBSRC (BB/P504835/1)
cam.issuedOnline2022-03-23
cam.orpheus.successTue Apr 12 08:22:44 BST 2022 - Embargo updated
cam.orpheus.counter2
cam.depositDate2022-03-10
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-03-23


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