Therapeutic maps for a sensor-based evaluation of deep brain stimulation programming.
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Authors
Berthold, Christophe
Krüger, Rejko
Koch, Klaus Peter
Gonçalves, Jorge
Hertel, Frank
Publication Date
2021-12-20Journal Title
Biomed Tech (Berl)
ISSN
0013-5585
Publisher
Walter de Gruyter GmbH
Volume
66
Issue
6
Pages
603-611
Type
Article
This Version
AM
Physical Medium
Electronic-Print
Metadata
Show full item recordCitation
Bremm, R. P., Berthold, C., Krüger, R., Koch, K. P., Gonçalves, J., & Hertel, F. (2021). Therapeutic maps for a sensor-based evaluation of deep brain stimulation programming.. Biomed Tech (Berl), 66 (6), 603-611. https://doi.org/10.1515/bmt-2020-0210
Abstract
Programming in deep brain stimulation (DBS) is a labour-intensive process for treating advanced motor symptoms. Specifically for patients with medication-refractory tremor in multiple sclerosis (MS). Wearable sensors are able to detect some manifestations of pathological signs, such as intention tremor in MS. However, methods are needed to visualise the response of tremor to DBS parameter changes in a clinical setting while patients perform the motor task finger-to-nose. To this end, we attended DBS programming sessions of a MS patient and intention tremor was effectively quantified by acceleration amplitude and frequency. A new method is introduced which results in the generation of therapeutic maps for a systematic review of the programming procedure in DBS. The maps visualise the combination of tremor acceleration power, clinical rating scores, total electrical energy delivered to the brain and possible side effects. Therapeutic maps have not yet been employed and could lead to a certain degree of standardisation for more objective decisions about DBS settings. The maps provide a base for future research on visualisation tools to assist physicians who frequently encounter patients for DBS therapy.
Keywords
accelerometers, deep brain stimulation, multiple sclerosis, short-time Fourier transform, tremor, Brain, Deep Brain Stimulation, Humans, Tremor
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1515/bmt-2020-0210
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334971
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