Assessment of neuropsychological function in brain tumor treatment: a comparison of traditional neuropsychological assessment with app-based cognitive screening.
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Authors
Owen, Mallory
McDonald, Alexa
Woodberry, Emma
Assem, Moataz
Coelho, Pedro
Morris, Rob C
Santarius, Tom
Manly, Tom
Erez, Yaara
Hart, Michael G
Publication Date
2022-03-01Journal Title
Acta Neurochir (Wien)
ISSN
0001-6268
Publisher
Springer Science and Business Media LLC
Pages
1-14
Type
Article
This Version
VoR
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Romero-Garcia, R., Owen, M., McDonald, A., Woodberry, E., Assem, M., Coelho, P., Morris, R. C., et al. (2022). Assessment of neuropsychological function in brain tumor treatment: a comparison of traditional neuropsychological assessment with app-based cognitive screening.. Acta Neurochir (Wien), 1-14. https://doi.org/10.1007/s00701-022-05162-5
Abstract
BACKGROUND: Gliomas are typically considered to cause relatively few neurological impairments. However, cognitive difficulties can arise, for example during treatment, with potential detrimental effects on quality of life. Accurate, reproducible, and accessible cognitive assessment is therefore vital in understanding the effects of both tumor and treatments. Our aim is to compare traditional neuropsychological assessment with an app-based cognitive screening tool in patients with glioma before and after surgical resection. Our hypotheses were that cognitive impairments would be apparent, even in a young and high functioning cohort, and that app-based cognitive screening would complement traditional neuropsychological assessment. METHODS: Seventeen patients with diffuse gliomas completed a traditional neuropsychological assessment and an app-based touchscreen tablet assessment pre- and post-operatively. The app assessment was also conducted at 3- and 12-month follow-up. Impairment rates, mean performance, and pre- and post-operative changes were compared using standardized Z-scores. RESULTS: Approximately 2-3 h of traditional assessment indicated an average of 2.88 cognitive impairments per patient, while the 30-min screen indicated 1.18. As might be expected, traditional assessment using multiple items across the difficulty range proved more sensitive than brief screening measures in areas such as memory and attention. However, the capacity of the screening app to capture reaction times enhanced its sensitivity, relative to traditional assessment, in the area of non-verbal function. Where there was overlap between the two assessments, for example digit span tasks, the results were broadly equivalent. CONCLUSIONS: Cognitive impairments were common in this sample and app-based screening complemented traditional neuropsychological assessment. Implications for clinical assessment and follow-up are discussed.
Keywords
Cognitive function, Glioma, Neuropsychiatry, Neuropsychology, Neurosurgery
Sponsorship
Cancer Research UK (A25117)
NIHR Academy (NIHRDH-CDF-2018-11-ST2-003)
Medical Research Council (MC_U105559837)
Medical Research Council (MC_UU_00005/10)
Identifiers
External DOI: https://doi.org/10.1007/s00701-022-05162-5
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334980
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