Show simple item record

dc.contributor.authorFazakerley, Daniel
dc.contributor.authorKoumanov, Francoise
dc.contributor.authorHolman, Geoffrey D
dc.date.accessioned2022-03-15T02:04:00Z
dc.date.available2022-03-15T02:04:00Z
dc.date.issued2022-02-11
dc.identifier.issn0264-6021
dc.identifier.otherPMC8883492
dc.identifier.other35147164
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334992
dc.description.abstractInsulin rapidly stimulates GLUT4 translocation and glucose transport in fat and muscle cells. Signals from the occupied insulin receptor are translated into downstream signalling changes in serine/threonine kinases within timescales of seconds, and this is followed by delivery and accumulation of the glucose transporter GLUT4 at the plasma membrane. Kinetic studies have led to realisation that there are distinct phases of this stimulation by insulin. There is a rapid initial burst of GLUT4 delivered to the cell surface from a subcellular reservoir compartment and this is followed by a steady-state level of continuing stimulation in which GLUT4 recycles through a large itinerary of subcellular locations. Here, we provide an overview of the phases of insulin stimulation of GLUT4 translocation and the molecules that are currently considered to activate these trafficking steps. Furthermore, we suggest how use of new experimental approaches together with phospho-proteomic data may help to further identify mechanisms for activation of these trafficking processes.
dc.languageeng
dc.publisherPortland Press
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 2984726R
dc.sourceessn: 1470-8728
dc.subjectInsulin
dc.subjectSignal transduction
dc.subjectGlucose transport
dc.subjectGLUT4
dc.subjectMembrane Traffic
dc.subjectMembrane Trafficking Kinetics
dc.subjectCell Membrane
dc.subjectSubcellular Fractions
dc.subjectAdipocytes
dc.subjectMuscle Cells
dc.subjectAnimals
dc.subjectHumans
dc.subjectGlucose
dc.subjectSignal Transduction
dc.subjectProtein Processing, Post-Translational
dc.subjectProtein Transport
dc.subjectPhosphorylation
dc.subjectModels, Biological
dc.subjectGlucose Transporter Type 4
dc.titleGLUT4 On the move.
dc.typeArticle
dc.date.updated2022-03-15T02:03:59Z
prism.endingPage462
prism.issueIdentifier3
prism.publicationNameBiochemical Journal
prism.startingPage445
prism.volume479
dc.identifier.doi10.17863/CAM.82430
dcterms.dateAccepted2022-01-14
rioxxterms.versionofrecord10.1042/BCJ20210073
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidFazakerley, Daniel [0000-0001-8241-2903]
dc.identifier.eissn1470-8728
pubs.funder-project-idMedical Research Council (MR/S007091/1)
cam.issuedOnline2022-02-11


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International