A phase I study investigating AZD8186, a potent and selective inhibitor of PI3Kβ/δ, in patients with advanced solid tumors.
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Authors
Higano, Celestia S
Rathkopf, Dana E
Martin-Liberal, Juan
Linch, Mark
de Bruin, Elza C
Colebrook, Steve
Hawkins, George
Klinowska, Teresa
Maroj, Brijesh
Moschetta, Michele
Nikolaou, Myria
Sainsbury, Liz
Publication Date
2022-03-04Journal Title
Clin Cancer Res
ISSN
1078-0432
Publisher
American Association for Cancer Research (AACR)
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Choudhury, A. D., Higano, C. S., de Bono, J. S., Cook, N., Rathkopf, D. E., Wisinski, K. B., Martin-Liberal, J., et al. (2022). A phase I study investigating AZD8186, a potent and selective inhibitor of PI3Kβ/δ, in patients with advanced solid tumors.. Clin Cancer Res https://doi.org/10.1158/1078-0432.CCR-21-3087
Abstract
PURPOSE: To characterize safety and tolerability of the selective PI3Kβ inhibitor AZD8186, identify a recommended phase II dose (RP2D), and assess preliminary efficacy in combination with abiraterone acetate or vistusertib. PATIENTS AND METHODS: This phase I open-label study included patients with advanced solid tumors, particularly prostate cancer, triple-negative breast cancer, and squamous non-small-cell lung cancer. The study comprised four arms: 1) AZD8186 monotherapy dose-finding; 2) monotherapy dose-expansion; 3) AZD8186/abiraterone acetate (with prednisone); and 4) AZD8186/vistusertib. The primary endpoints were safety, tolerability, and identification of the RP2D of AZD8186 monotherapy and in combination. Secondary endpoints included pharmacokinetics, pharmacodynamics, and tumor and prostate-specific antigen (PSA) responses. RESULTS: In total, 161 patients were enrolled. AZD8186 was well tolerated across all study arms, the most common adverse events being gastrointestinal symptoms. In the monotherapy dose-finding arm, four patients experienced dose-limiting toxicities (mainly rash). AZD8186 doses of 60 mg twice daily (BID; 5 days on, 2 days off [5:2]) and 120 mg BID (continuous and 5:2 dosing) were taken into subsequent arms. The pharmacokinetics of AZD8186 were dose proportional, without interactions with abiraterone acetate or vistusertib, and target inhibition was observed in plasma and tumor tissue. Monotherapy and combination therapy showed preliminary evidence of limited anti-tumor activity by imaging and, in prostate cancer, PSA reduction. CONCLUSIONS: AZD8186 monotherapy had an acceptable safety and tolerability profile, and combination with abiraterone acetate/prednisone or vistusertib was also tolerated. There was preliminary evidence of anti-tumor activity, meriting further exploration of AZD8186 in subsequent studies in PI3Kb-pathway-dependent cancers.
Embargo Lift Date
2023-03-04
Identifiers
External DOI: https://doi.org/10.1158/1078-0432.CCR-21-3087
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335028
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