CHROMOMETHYLTRANSFERASE3/KRYPTONITE maintains the sulfurea paramutation in Solanum lycopersicum.
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Authors
Wang, Zhengming
Yarur, Antonia
Müller, Sebastian
Publication Date
2022-03-29Journal Title
Proc Natl Acad Sci U S A
ISSN
0027-8424
Publisher
Proceedings of the National Academy of Sciences
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Martinho, C., Wang, Z., Ghigi, A., Buddle, S., Barbour, F., Yarur, A., Gouil, Q., et al. (2022). CHROMOMETHYLTRANSFERASE3/KRYPTONITE maintains the sulfurea paramutation in Solanum lycopersicum.. Proc Natl Acad Sci U S A https://doi.org/10.1073/pnas.2112240119
Abstract
SignificanceParamutation involves the transfer of a repressive epigenetic mark between silent and active alleles. It is best known from exceptional non-Mendelian inheritance of conspicuous phenotypes in maize but also in other plants and animals. Recent genomic studies, however, indicate that paramutation may be less exceptional. It may be a consequence of wide-cross hybridization and may contribute to quantitative trait variation or unstable phenotypes in crops. Using the sulfurea (sulf) locus in tomato, we demonstrate that a self-reinforcing feedback loop involving DNA- and histone-methyl transferases CHROMOMETHYLTRANSFERASE3 (CMT3) and KRYPTONITE (KYP) is required for paramutation of sulf and that there is a change in chromatin organization. These findings advance the understanding of non-Mendelian inheritance in plants.
Sponsorship
This study was supported by the BBSRC grant PDAG/387 RG87392
Funder references
Biotechnology and Biological Sciences Research Council (BB/P020321/1)
Identifiers
External DOI: https://doi.org/10.1073/pnas.2112240119
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335035
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