CHROMOMETHYLTRANSFERASE3/KRYPTONITE maintains the sulfurea paramutation in Solanum lycopersicum.
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences
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Martinho, C., Wang, Z., Ghigi, A., Buddle, S., Barbour, F., Yarur, A., Gouil, Q., et al. (2022). CHROMOMETHYLTRANSFERASE3/KRYPTONITE maintains the sulfurea paramutation in Solanum lycopersicum.. Proc Natl Acad Sci U S A https://doi.org/10.1073/pnas.2112240119
SignificanceParamutation involves the transfer of a repressive epigenetic mark between silent and active alleles. It is best known from exceptional non-Mendelian inheritance of conspicuous phenotypes in maize but also in other plants and animals. Recent genomic studies, however, indicate that paramutation may be less exceptional. It may be a consequence of wide-cross hybridization and may contribute to quantitative trait variation or unstable phenotypes in crops. Using the sulfurea (sulf) locus in tomato, we demonstrate that a self-reinforcing feedback loop involving DNA- and histone-methyl transferases CHROMOMETHYLTRANSFERASE3 (CMT3) and KRYPTONITE (KYP) is required for paramutation of sulf and that there is a change in chromatin organization. These findings advance the understanding of non-Mendelian inheritance in plants.
This study was supported by the BBSRC grant PDAG/387 RG87392
Biotechnology and Biological Sciences Research Council (BB/P020321/1)
External DOI: https://doi.org/10.1073/pnas.2112240119
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335035
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