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dc.contributor.authorMartinho, Cláudia
dc.contributor.authorWang, Zhengming
dc.contributor.authorGhigi, Andrea
dc.contributor.authorBuddle, Sarah
dc.contributor.authorBarbour, Felix
dc.contributor.authorYarur, Antonia
dc.contributor.authorGouil, Quentin
dc.contributor.authorMüller, Sebastian
dc.contributor.authorStam, Maike
dc.contributor.authorLiu, Chang
dc.contributor.authorBaulcombe, David
dc.date.accessioned2022-03-16T00:30:28Z
dc.date.available2022-03-16T00:30:28Z
dc.date.issued2022-03-29
dc.identifier.issn0027-8424
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335035
dc.description.abstractSignificanceParamutation involves the transfer of a repressive epigenetic mark between silent and active alleles. It is best known from exceptional non-Mendelian inheritance of conspicuous phenotypes in maize but also in other plants and animals. Recent genomic studies, however, indicate that paramutation may be less exceptional. It may be a consequence of wide-cross hybridization and may contribute to quantitative trait variation or unstable phenotypes in crops. Using the sulfurea (sulf) locus in tomato, we demonstrate that a self-reinforcing feedback loop involving DNA- and histone-methyl transferases CHROMOMETHYLTRANSFERASE3 (CMT3) and KRYPTONITE (KYP) is required for paramutation of sulf and that there is a change in chromatin organization. These findings advance the understanding of non-Mendelian inheritance in plants.
dc.description.sponsorshipThis study was supported by the BBSRC grant PDAG/387 RG87392
dc.publisherProceedings of the National Academy of Sciences
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleCHROMOMETHYLTRANSFERASE3/KRYPTONITE maintains the sulfurea paramutation in Solanum lycopersicum.
dc.typeArticle
dc.publisher.departmentDepartment of Plant Sciences
dc.date.updated2022-03-15T10:32:39Z
prism.publicationDate2022
prism.publicationNameProc Natl Acad Sci U S A
dc.identifier.doi10.17863/CAM.82474
dcterms.dateAccepted2022-01-21
rioxxterms.versionofrecord10.1073/pnas.2112240119
rioxxterms.versionAM
dc.contributor.orcidMartinho, Cláudia [0000-0003-0151-6634]
dc.contributor.orcidGhigi, Andrea [0000-0001-9876-5869]
dc.contributor.orcidBuddle, Sarah [0000-0002-4738-9469]
dc.contributor.orcidBarbour, Felix [0000-0002-8979-2379]
dc.contributor.orcidGouil, Quentin [0000-0002-5142-7886]
dc.contributor.orcidStam, Maike [0000-0003-0363-4677]
dc.contributor.orcidLiu, Chang [0000-0003-2859-4288]
dc.contributor.orcidBaulcombe, David [0000-0003-0780-6878]
dc.identifier.eissn1091-6490
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/P020321/1)
cam.issuedOnline2022-03-24
cam.orpheus.success2022-03-15 - Embargo set during processing via Fast-track
cam.depositDate2022-03-15
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2022-03-31


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