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dc.contributor.authorLefrancq, Noemie
dc.contributor.authorBouchez, Valérie
dc.contributor.authorFernandes, Nadia
dc.contributor.authorBarkoff, Alex-Mikael
dc.contributor.authorBosch, Thijs
dc.contributor.authorDalby, Tine
dc.contributor.authorÅkerlund, Thomas
dc.contributor.authorDarenberg, Jessica
dc.contributor.authorFabianova, Katerina
dc.contributor.authorVestrheim, Didrik F
dc.contributor.authorFry, Norman K
dc.contributor.authorGonzález-López, Juan José
dc.contributor.authorGullsby, Karolina
dc.contributor.authorHabington, Adele
dc.contributor.authorHe, Qiushui
dc.contributor.authorLitt, David
dc.contributor.authorMartini, Helena
dc.contributor.authorPiérard, Denis
dc.contributor.authorStefanelli, Paola
dc.contributor.authorStegger, Marc
dc.contributor.authorZavadilova, Jana
dc.contributor.authorArmatys, Nathalie
dc.contributor.authorLandier, Annie
dc.contributor.authorGuillot, Sophie
dc.contributor.authorHong, Samuel L
dc.contributor.authorLemey, Philippe
dc.contributor.authorParkhill, Julian
dc.contributor.authorToubiana, Julie
dc.contributor.authorCauchemez, Simon
dc.contributor.authorSalje, Henrik
dc.contributor.authorBrisse, Sylvain
dc.date.accessioned2022-03-16T00:30:40Z
dc.date.available2022-03-16T00:30:40Z
dc.date.issued2022-04-27
dc.identifier.issn1946-6234
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335039
dc.description.abstractAs with other pathogens, competitive interactions between Bordetella pertussis strains drive infection risk. Vaccines are thought to perturb strain diversity through shifts in immune pressures; however, this has rarely been measured because of inadequate data and analytical tools. We used 3344 sequences from 23 countries to show that, on average, there are 28.1 transmission chains circulating within a subnational region, with the number of chains strongly associated with host population size. It took 5 to 10 years for B. pertussis to be homogeneously distributed throughout Europe, with the same time frame required for the United States. Increased fitness of pertactin-deficient strains after implementation of acellular vaccines, but reduced fitness otherwise, can explain long-term genotype dynamics. These findings highlight the role of vaccine policy in shifting local diversity of a pathogen that is responsible for 160,000 deaths annually.
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleGlobal spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis.
dc.typeArticle
dc.publisher.departmentDepartment of Genetics
dc.date.updated2022-03-15T12:42:01Z
prism.publicationNameSci Transl Med
dc.identifier.doi10.17863/CAM.82478
dcterms.dateAccepted2022-03-10
rioxxterms.versionofrecord10.1126/scitranslmed.abn3253
rioxxterms.versionAM
dc.contributor.orcidLefrancq, Noemie [0000-0001-5991-6169]
dc.contributor.orcidBouchez, Valérie [0000-0002-5947-6383]
dc.contributor.orcidFernandes, Nadia [0000-0003-4595-9939]
dc.contributor.orcidDalby, Tine [0000-0003-4774-7091]
dc.contributor.orcidÅkerlund, Thomas [0000-0001-7516-0218]
dc.contributor.orcidDarenberg, Jessica [0000-0002-8528-8570]
dc.contributor.orcidFabianova, Katerina [0000-0001-8374-4395]
dc.contributor.orcidFry, Norman K [0000-0003-4862-6507]
dc.contributor.orcidGonzález-López, Juan José [0000-0003-2419-5909]
dc.contributor.orcidGullsby, Karolina [0000-0002-9673-0483]
dc.contributor.orcidHabington, Adele [0000-0001-6997-3327]
dc.contributor.orcidLitt, David [0000-0002-9215-0553]
dc.contributor.orcidMartini, Helena [0000-0002-5877-9948]
dc.contributor.orcidPiérard, Denis [0000-0002-7756-3691]
dc.contributor.orcidStefanelli, Paola [0000-0003-1620-4385]
dc.contributor.orcidStegger, Marc [0000-0003-0321-1180]
dc.contributor.orcidArmatys, Nathalie [0000-0003-2042-4241]
dc.contributor.orcidLandier, Annie [0000-0002-8278-4026]
dc.contributor.orcidHong, Samuel L [0000-0001-6354-4943]
dc.contributor.orcidLemey, Philippe [0000-0003-2826-5353]
dc.contributor.orcidParkhill, Julian [0000-0002-7069-5958]
dc.contributor.orcidCauchemez, Simon [0000-0001-9186-4549]
dc.contributor.orcidSalje, Henrik [0000-0003-3626-4254]
dc.contributor.orcidBrisse, Sylvain [0000-0002-2516-2108]
dc.identifier.eissn1946-6242
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) ERC (804744)
cam.orpheus.successWed May 25 11:13:23 BST 2022 - Embargo updated
cam.orpheus.counter4
cam.depositDate2022-03-15
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2022-04-27


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