Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study.
Authors
Törn, Carina
Liu, Xiang
Onengut-Gumuscu, Suna
Counts, Kevin M
Moreno, Jose Leonardo
Remedios, Cassandra L
Chen, Wei-Min
LeFaive, Jonathon
Butterworth, Martha D
Akolkar, Beena
Krischer, Jeffrey P
Lernmark, Åke
Rewers, Marian
She, Jin-Xiong
Toppari, Jorma
Ziegler, Anette-Gabriele
Ratan, Aakrosh
Smith, Albert V
Hagopian, William A
Rich, Stephen S
Parikh, Hemang M
TEDDY Study Group
Publication Date
2022-03-16Journal Title
Sci Rep
ISSN
2045-2322
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Törn, C., Liu, X., Onengut-Gumuscu, S., Counts, K. M., Moreno, J. L., Remedios, C. L., Chen, W., et al. (2022). Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study.. Sci Rep, 12 (1) https://doi.org/10.1038/s41598-022-08058-7
Description
Funder: Lund University
Abstract
The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8676 children, 3-4 months of age, born with HLA-susceptibility genotypes for islet autoimmunity (IA) and type 1 diabetes (T1D). Whole-genome sequencing (WGS) was performed in 1119 children in a nested case-control study design. Telomere length was estimated from WGS data using five tools: Computel, Telseq, Telomerecat, qMotif and Motif_counter. The estimated median telomere length was 5.10 kb (IQR 4.52-5.68 kb) using Computel. The age when the blood sample was drawn had a significant negative correlation with telomere length (P = 0.003). European children, particularly those from Finland (P = 0.041) and from Sweden (P = 0.001), had shorter telomeres than children from the U.S.A. Paternal age (P = 0.019) was positively associated with telomere length. First-degree relative status, presence of gestational diabetes in the mother, and maternal age did not have a significant impact on estimated telomere length. HLA-DR4/4 or HLA-DR4/X children had significantly longer telomeres compared to children with HLA-DR3/3 or HLA-DR3/9 haplogenotypes (P = 0.008). Estimated telomere length was not significantly different with respect to any IA (P = 0.377), IAA-first (P = 0.248), GADA-first (P = 0.248) or T1D (P = 0.861). These results suggest that telomere length has no major impact on the risk for IA, the first step to develop T1D. Nevertheless, telomere length was shorter in the T1D high prevalence populations, Finland and Sweden.
Keywords
Article, /631/114, /631/208, /692/163, article
Sponsorship
National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) (U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829, U01 DK63829)
Identifiers
s41598-022-08058-7, 8058
External DOI: https://doi.org/10.1038/s41598-022-08058-7
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335093
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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