Mechanisms of Choice in X-Chromosome Inactivation.
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Publication Date
2022-02-03Journal Title
Cells
ISSN
2073-4409
Publisher
MDPI AG
Volume
11
Issue
3
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Furlan, G., & Galupa, R. (2022). Mechanisms of Choice in X-Chromosome Inactivation.. Cells, 11 (3) https://doi.org/10.3390/cells11030535
Abstract
Early in development, placental and marsupial mammals harbouring at least two X chromosomes per nucleus are faced with a choice that affects the rest of their lives: which of those X chromosomes to transcriptionally inactivate. This choice underlies phenotypical diversity in the composition of tissues and organs and in their response to the environment, and can determine whether an individual will be healthy or affected by an X-linked disease. Here, we review our current understanding of the process of choice during X-chromosome inactivation and its implications, focusing on the strategies evolved by different mammalian lineages and on the known and unknown molecular mechanisms and players involved.
Keywords
X-chromosome Inactivation, Marsupials, Skewing, Placentals, Allelic Choice
Sponsorship
European Molecular Biology Organization (EMBO ALTF 1132-2018)
Marie Skłodowska-Curie Actions (COFUND 664726)
Identifiers
35159344, PMC8833938
External DOI: https://doi.org/10.3390/cells11030535
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335208
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