100 years post-insulin: immunotherapy as the next frontier in type 1 diabetes.
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Publication Date
2021-01Journal Title
Immunother Adv
ISSN
2732-4303
Publisher
Oxford University Press (OUP)
Volume
1
Issue
1
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Pearson, J. A., McKinney, E. F., & Walker, L. S. (2021). 100 years post-insulin: immunotherapy as the next frontier in type 1 diabetes.. Immunother Adv, 1 (1) https://doi.org/10.1093/immadv/ltab024
Abstract
Type 1 diabetes (T1D) is an autoimmune disease characterised by T cell-mediated destruction of the insulin-producing β cells in the pancreas. Similar to other autoimmune diseases, the incidence of T1D is increasing globally. The discovery of insulin 100 years ago dramatically changed the outlook for people with T1D, preventing this from being a fatal condition. As we celebrate the centenary of this milestone, therapeutic options for T1D are once more at a turning point. Years of effort directed at developing immunotherapies are finally starting to pay off, with signs of progress in new onset and even preventative settings. Here, we review a selection of immunotherapies that have shown promise in preserving β cell function and highlight future considerations for immunotherapy in the T1D setting.
Keywords
Human, Immunotherapy, type 1 diabetes, Nod Mouse
Sponsorship
Medical Research Council (MR/S009140/1, MR/N001435/1)
Wellcome Trust (220772/Z/20/Z)
Diabetes UK (20/0006172)
Identifiers
35156097, PMC8826223
External DOI: https://doi.org/10.1093/immadv/ltab024
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335214
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