Show simple item record

dc.contributor.authorBadenoch, James B
dc.contributor.authorRengasamy, Emma R
dc.contributor.authorWatson, Cameron
dc.contributor.authorJansen, Katrin
dc.contributor.authorChakraborty, Stuti
dc.contributor.authorSundaram, Ritika D
dc.contributor.authorHafeez, Danish
dc.contributor.authorBurchill, Ella
dc.contributor.authorSaini, Aman
dc.contributor.authorThomas, Lucretia
dc.contributor.authorCross, Benjamin
dc.contributor.authorHunt, Camille K
dc.contributor.authorConti, Isabella
dc.contributor.authorRalovska, Sylvia
dc.contributor.authorHussain, Zain
dc.contributor.authorButler, Matthew
dc.contributor.authorPollak, Thomas A
dc.contributor.authorKoychev, Ivan
dc.contributor.authorMichael, Benedict D
dc.contributor.authorHolling, Heinz
dc.contributor.authorNicholson, Timothy R
dc.contributor.authorRogers, Jonathan P
dc.contributor.authorRooney, Alasdair G
dc.date.accessioned2022-03-20T02:02:22Z
dc.date.available2022-03-20T02:02:22Z
dc.date.issued2022
dc.identifier.issn2632-1297
dc.identifier.other35169700
dc.identifier.otherPMC8833580
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335231
dc.description.abstractThe nature and extent of persistent neuropsychiatric symptoms after COVID-19 are not established. To help inform mental health service planning in the pandemic recovery phase, we systematically determined the prevalence of neuropsychiatric symptoms in survivors of COVID-19. For this pre-registered systematic review and meta-analysis (PROSPERO ID CRD42021239750), we searched MEDLINE, EMBASE, CINAHL and PsycINFO to 20 February 2021, plus our own curated database. We included peer-reviewed studies reporting neuropsychiatric symptoms at post-acute or later time-points after COVID-19 infection and in control groups where available. For each study, a minimum of two authors extracted summary data. For each symptom, we calculated a pooled prevalence using generalized linear mixed models. Heterogeneity was measured with I 2. Subgroup analyses were conducted for COVID-19 hospitalization, severity and duration of follow-up. From 2844 unique titles, we included 51 studies (n = 18 917 patients). The mean duration of follow-up after COVID-19 was 77 days (range 14-182 days). Study quality was most commonly moderate. The most prevalent neuropsychiatric symptom was sleep disturbance [pooled prevalence = 27.4% (95% confidence interval 21.4-34.4%)], followed by fatigue [24.4% (17.5-32.9%)], objective cognitive impairment [20.2% (10.3-35.7%)], anxiety [19.1% (13.3-26.8%)] and post-traumatic stress [15.7% (9.9-24.1%)]. Only two studies reported symptoms in control groups, both reporting higher frequencies in COVID-19 survivors versus controls. Between-study heterogeneity was high (I 2 = 79.6-98.6%). There was little or no evidence of differential symptom prevalence based on hospitalization status, severity or follow-up duration. Neuropsychiatric symptoms are common and persistent after recovery from COVID-19. The literature on longer-term consequences is still maturing but indicates a particularly high prevalence of insomnia, fatigue, cognitive impairment and anxiety disorders in the first 6 months after infection.
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2632-1297
dc.sourcenlmid: 101755125
dc.subjectNeuropsychiatry
dc.subjectCovid-19
dc.subjectLong Covid
dc.subjectChronic Covid Syndrome
dc.subjectPost-Acute Sequelae Of Covid-19
dc.titlePersistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysis.
dc.typeArticle
dc.date.updated2022-03-20T02:02:17Z
prism.issueIdentifier1
prism.publicationNameBrain Commun
prism.volume4
dc.identifier.doi10.17863/CAM.82661
dcterms.dateAccepted2021-12-15
rioxxterms.versionofrecord10.1093/braincomms/fcab297
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidBadenoch, James B [0000-0002-6994-6916]
dc.contributor.orcidHafeez, Danish [0000-0003-3712-136X]
dc.contributor.orcidBurchill, Ella [0000-0002-1674-8844]
dc.contributor.orcidPollak, Thomas A [0000-0002-6171-0810]
dc.contributor.orcidRogers, Jonathan P [0000-0002-4671-5410]
dc.identifier.eissn2632-1297
pubs.funder-project-idMedical Research Foundation (C0396)
pubs.funder-project-idWellcome Trust (102186/B/13/Z)
pubs.funder-project-idMedical Research Council (MR/J000914/1)
cam.issuedOnline2021-12-17


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International