A spatial model of the plant circadian clock reveals design principles for coordinated timing.
Publication Date
2022-03Journal Title
Mol Syst Biol
ISSN
1744-4292
Publisher
EMBO
Volume
18
Issue
3
Language
en
Type
Article
This Version
AO
VoR
Metadata
Show full item recordCitation
Greenwood, M., Tokuda, I. T., & Locke, J. (2022). A spatial model of the plant circadian clock reveals design principles for coordinated timing.. Mol Syst Biol, 18 (3) https://doi.org/10.15252/msb.202010140
Abstract
Individual plant cells possess a genetic network, the circadian clock, that times internal processes to the day-night cycle. Mathematical models of the clock are typically either "whole-plant" that ignore tissue or cell type-specific clock behavior, or "phase-only" that do not include molecular components. To address the complex spatial coordination observed in experiments, here we implemented a clock network model on a template of a seedling. In our model, the sensitivity to light varies across the plant, and cells communicate their timing via local or long-distance sharing of clock components, causing their rhythms to couple. We found that both varied light sensitivity and long-distance coupling could generate period differences between organs, while local coupling was required to generate the spatial waves of clock gene expression observed experimentally. We then examined our model under noisy light-dark cycles and found that local coupling minimized timing errors caused by the noise while allowing each plant region to maintain a different clock phase. Thus, local sensitivity to environmental inputs combined with local coupling enables flexible yet robust circadian timing.
Keywords
EMBO30, Article, Articles, circadian clock, coordination, coupling, noise, plant
Sponsorship
Gatsby Charitable Foundation (unknown)
Identifiers
msb202010140
External DOI: https://doi.org/10.15252/msb.202010140
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335250
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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