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dc.contributor.authorGreenwood, Mark
dc.contributor.authorTokuda, Isao T
dc.contributor.authorLocke, James
dc.date.accessioned2022-03-21T11:00:10Z
dc.date.available2022-03-21T11:00:10Z
dc.date.issued2022-03
dc.date.submitted2020-11-23
dc.identifier.issn1744-4292
dc.identifier.othermsb202010140
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335250
dc.description.abstractIndividual plant cells possess a genetic network, the circadian clock, that times internal processes to the day-night cycle. Mathematical models of the clock are typically either "whole-plant" that ignore tissue or cell type-specific clock behavior, or "phase-only" that do not include molecular components. To address the complex spatial coordination observed in experiments, here we implemented a clock network model on a template of a seedling. In our model, the sensitivity to light varies across the plant, and cells communicate their timing via local or long-distance sharing of clock components, causing their rhythms to couple. We found that both varied light sensitivity and long-distance coupling could generate period differences between organs, while local coupling was required to generate the spatial waves of clock gene expression observed experimentally. We then examined our model under noisy light-dark cycles and found that local coupling minimized timing errors caused by the noise while allowing each plant region to maintain a different clock phase. Thus, local sensitivity to environmental inputs combined with local coupling enables flexible yet robust circadian timing.
dc.languageen
dc.publisherEMBO
dc.subjectEMBO30
dc.subjectArticle
dc.subjectArticles
dc.subjectcircadian clock
dc.subjectcoordination
dc.subjectcoupling
dc.subjectnoise
dc.subjectplant
dc.titleA spatial model of the plant circadian clock reveals design principles for coordinated timing.
dc.typeArticle
dc.date.updated2022-03-21T11:00:09Z
prism.issueIdentifier3
prism.publicationNameMol Syst Biol
prism.volume18
dc.identifier.doi10.17863/CAM.82682
dcterms.dateAccepted2022-02-21
rioxxterms.versionofrecord10.15252/msb.202010140
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidGreenwood, Mark [0000-0002-2652-6647]
dc.contributor.orcidTokuda, Isao T [0000-0001-6212-0022]
dc.contributor.orcidLocke, James [0000-0003-0670-1943]
dc.identifier.eissn1744-4292
pubs.funder-project-idGatsby Charitable Foundation (unknown)
cam.issuedOnline2022-03-21


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