Endothelin-1 is Increased in the Plasma of Patients Hospitalized with Covid-19
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Authors
Abraham, George
Kuc, Rhoda
Althage, Magnus
Greasley, Peter
Ambery, Philip
Hoole, Stephen
Publication Date
2022-06Journal Title
Journal of Molecular and Cellular Cardiology
ISSN
0022-2828
Publisher
Elsevier
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Abraham, G., Kuc, R., Althage, M., Greasley, P., Ambery, P., Maguire, J., Wilkinson, I., et al. (2022). Endothelin-1 is Increased in the Plasma of Patients Hospitalized with Covid-19. Journal of Molecular and Cellular Cardiology https://doi.org/10.1016/j.yjmcc.2022.03.007
Abstract
Virus induced endothelial dysregulation is a well-recognised feature of severe Covid-19 infection. Endothelin-1 (ET-1) is the most highly expressed peptide in endothelial cells and a potent vasoconstrictor, thus representing a potential therapeutic target.
ET-1 plasma levels were measured in a cohort of 194 Covid-19 patients stratified according to the clinical severity of their illness. Hospitalised patients, including those who died and those developing acute myocardial or kidney injury, had significantly elevated ET-1 plasma levels during the acute phase of infection.
The results support the hypothesis that endothelin receptor antagonists may provide clinical benefit for certain Covid-19 patients.
Sponsorship
Supported in full or part by The Jon Moulton Charity Trust, National Institute of Health Research, Cambridge Biomedical Research Centre, BRC-1215-20014 (JC); Wellcome Trust (WT107715/Z/15/Z), Biomedical Resources Grant, University of Cambridge, Cardiovascular Theme RG64226, British Heart Foundation, TG/18/4/33770,
Funder references
Wellcome Trust (107715/Z/15/Z)
British Heart Foundation (TG/18/4/33770)
MRC (via University of Glasgow) (303684)
National Institute for Health Research (IS-BRC-1215-20014)
Identifiers
External DOI: https://doi.org/10.1016/j.yjmcc.2022.03.007
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335274
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