Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19.
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Authors
Abraham, George R
Kuc, Rhoda E
Althage, Magnus
Greasley, Peter J
Ambery, Philip
Hoole, Stephen P
Publication Date
2022-03-23Journal Title
J Mol Cell Cardiol
ISSN
0022-2828
Publisher
Elsevier BV
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Abraham, G. R., Kuc, R. E., Althage, M., Greasley, P. J., Ambery, P., Maguire, J., Wilkinson, I., et al. (2022). Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19.. J Mol Cell Cardiol https://doi.org/10.1016/j.yjmcc.2022.03.007
Abstract
Virus induced endothelial dysregulation is a well-recognised feature of severe Covid-19 infection. Endothelin-1 (ET-1) is the most highly expressed peptide in endothelial cells and a potent vasoconstrictor, thus representing a potential therapeutic target. ET-1 plasma levels were measured in a cohort of 194 Covid-19 patients stratified according to the clinical severity of their illness. Hospitalised patients, including those who died and those developing acute myocardial or kidney injury, had significantly elevated ET-1 plasma levels during the acute phase of infection. The results support the hypothesis that endothelin receptor antagonists may provide clinical benefit for certain Covid-19 patients.
Sponsorship
Supported in full or part by The Jon Moulton Charity Trust, National Institute of Health Research, Cambridge Biomedical Research Centre, BRC-1215-20014 (JC); Wellcome Trust (WT107715/Z/15/Z), Biomedical Resources Grant, University of Cambridge, Cardiovascular Theme RG64226, British Heart Foundation, TG/18/4/33770,
Funder references
Wellcome Trust (107715/Z/15/Z)
British Heart Foundation (TG/18/4/33770)
MRC (via University of Glasgow) (303684)
National Institute for Health Research (NIHRDH-IS-BRC-1215-20014)
Embargo Lift Date
2023-03-23
Identifiers
External DOI: https://doi.org/10.1016/j.yjmcc.2022.03.007
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335274
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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