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dc.contributor.authorWolpe, Noham
dc.contributor.authorHezemans, Frank H
dc.contributor.authorRae, Charlotte
dc.contributor.authorZhang, Jiaxiang
dc.contributor.authorRowe, James
dc.date.accessioned2022-03-26T00:30:11Z
dc.date.available2022-03-26T00:30:11Z
dc.date.issued2022-07
dc.identifier.issn0010-9452
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335346
dc.description.abstractThe pre-supplementary motor area (pre-SMA) is central for the initiation and inhibition of voluntary action. For the execution of action, the pre-SMA optimises the decision of which action to choose by adjusting the thresholds for the required evidence for each choice. However, it remains unclear how the pre-SMA contributes to action inhibition. Here, we use computational modelling of a stop/no-go task, performed by an adult with a focal lesion in the pre-SMA, and 52 age-matched controls. We show that the patient required more time to successfully inhibit an action (longer stop-signal reaction time) but was faster in terms of go reaction times. Computational modelling revealed that the patient’s failure to stop was explained by a significantly lower response threshold for initiating an action, as compared to controls, suggesting that the patient needed less evidence before committing to an action. A similarly specific impairment was also observed for the decision of which action to choose. Together, our results suggest that dynamic threshold modulation may be a general mechanism by which the pre-SMA exerts its control over voluntary action.
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleThe pre-supplementary motor area achieves inhibitory control by modulating response thresholds
dc.typeArticle
dc.publisher.departmentDepartment of Clinical Neurosciences
dc.date.updated2022-03-23T13:39:59Z
prism.publicationNameCortex
dc.identifier.doi10.17863/CAM.82778
dcterms.dateAccepted2022-03-19
rioxxterms.versionofrecord10.1016/j.cortex.2022.03.018
rioxxterms.versionAM
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.identifier.eissn1973-8102
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (103838/Z/14/Z)
pubs.funder-project-idMedical Research Council (MC_UU_00005/12)
cam.orpheus.successWed May 25 11:13:26 BST 2022 - Embargo updated
cam.orpheus.counter3
cam.depositDate2022-03-23
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-04-14


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International