Regional Haemodynamic and Metabolic Coupling in Infants.
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Authors
Siddiqui, Maheen F
Pinti, Paola
Jones, Emily JH
Brigadoi, Sabrina
Collins-Jones, Liam
Tachtsidis, Ilias
Johnson, Mark H
Elwell, Clare E
Publication Date
2021Journal Title
Front Hum Neurosci
ISSN
1662-5161
Publisher
Frontiers Media SA
Volume
15
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Siddiqui, M. F., Pinti, P., Lloyd-Fox, S., Jones, E. J., Brigadoi, S., Collins-Jones, L., Tachtsidis, I., et al. (2021). Regional Haemodynamic and Metabolic Coupling in Infants.. Front Hum Neurosci, 15 https://doi.org/10.3389/fnhum.2021.780076
Abstract
Metabolic pathways underlying brain function remain largely unexplored during neurodevelopment, predominantly due to the lack of feasible techniques for use with awake infants. Broadband near-infrared spectroscopy (bNIRS) provides the opportunity to explore the relationship between cerebral energy metabolism and blood oxygenation/haemodynamics through the measurement of changes in the oxidation state of mitochondrial respiratory chain enzyme cytochrome-c-oxidase (ΔoxCCO) alongside haemodynamic changes. We used a bNIRS system to measure ΔoxCCO and haemodynamics during functional activation in a group of 42 typically developing infants aged between 4 and 7 months. bNIRS measurements were made over the right hemisphere over temporal, parietal and central cortical regions, in response to social and non-social visual and auditory stimuli. Both ΔoxCCO and Δ[HbO2] displayed larger activation for the social condition in comparison to the non-social condition. Integration of haemodynamic and metabolic signals revealed networks of stimulus-selective cortical regions that were not apparent from analysis of the individual bNIRS signals. These results provide the first spatially resolved measures of cerebral metabolic activity alongside haemodynamics during functional activation in infants. Measuring synchronised changes in metabolism and haemodynamics have the potential for uncovering the development of cortical specialisation in early infancy.
Keywords
Mitochondria, Metabolism, Neurodevelopment, Neurovascular Coupling, Social Brain, Brain Metabolic Imaging, Brain Specialization, Fnirs (Functional Near Infrared Spectroscopy)
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/J014567/1)
Economic and Social Research Council (ES/V012436/1)
Wellcome Trust (104580/Z/14/Z)
Identifiers
35185494, PMC8854371
External DOI: https://doi.org/10.3389/fnhum.2021.780076
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335392
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