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dc.contributor.authorKaura, Amit
dc.contributor.authorHartley, Adam
dc.contributor.authorPanoulas, Vasileios
dc.contributor.authorGlampson, Ben
dc.contributor.authorShah, Anoop SV
dc.contributor.authorDavies, Jim
dc.contributor.authorMulla, Abdulrahim
dc.contributor.authorWoods, Kerrie
dc.contributor.authorOmigie, Joe
dc.contributor.authorShah, Anoop D
dc.contributor.authorThursz, Mark R
dc.contributor.authorElliott, Paul
dc.contributor.authorHemmingway, Harry
dc.contributor.authorWilliams, Bryan
dc.contributor.authorAsselbergs, Folkert W
dc.contributor.authorO'Sullivan, Michael
dc.contributor.authorLord, Graham M
dc.contributor.authorTrickey, Adam
dc.contributor.authorSterne, Jonathan Ac
dc.contributor.authorHaskard, Dorian O
dc.contributor.authorMelikian, Narbeh
dc.contributor.authorFrancis, Darrel P
dc.contributor.authorKoenig, Wolfgang
dc.contributor.authorShah, Ajay M
dc.contributor.authorKharbanda, Rajesh
dc.contributor.authorPerera, Divaka
dc.contributor.authorPatel, Riyaz S
dc.contributor.authorChannon, Keith M
dc.contributor.authorMayet, Jamil
dc.contributor.authorKhamis, Ramzi
dc.date.accessioned2022-03-28T19:06:15Z
dc.date.available2022-03-28T19:06:15Z
dc.date.issued2022-02
dc.identifier.issn1549-1277
dc.identifier.other35192610
dc.identifier.otherPMC8863282
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335410
dc.description.abstractBACKGROUND: There is limited evidence on the use of high-sensitivity C-reactive protein (hsCRP) as a biomarker for selecting patients for advanced cardiovascular (CV) therapies in the modern era. The prognostic value of mildly elevated hsCRP beyond troponin in a large real-world cohort of unselected patients presenting with suspected acute coronary syndrome (ACS) is unknown. We evaluated whether a mildly elevated hsCRP (up to 15 mg/L) was associated with mortality risk, beyond troponin level, in patients with suspected ACS. METHODS AND FINDINGS: We conducted a retrospective cohort study based on the National Institute for Health Research Health Informatics Collaborative data of 257,948 patients with suspected ACS who had a troponin measured at 5 cardiac centres in the United Kingdom between 2010 and 2017. Patients were divided into 4 hsCRP groups (<2, 2 to 4.9, 5 to 9.9, and 10 to 15 mg/L). The main outcome measure was mortality within 3 years of index presentation. The association between hsCRP levels and all-cause mortality was assessed using multivariable Cox regression analysis adjusted for age, sex, haemoglobin, white cell count (WCC), platelet count, creatinine, and troponin. Following the exclusion criteria, there were 102,337 patients included in the analysis (hsCRP <2 mg/L (n = 38,390), 2 to 4.9 mg/L (n = 27,397), 5 to 9.9 mg/L (n = 26,957), and 10 to 15 mg/L (n = 9,593)). On multivariable Cox regression analysis, there was a positive and graded relationship between hsCRP level and mortality at baseline, which remained at 3 years (hazard ratio (HR) (95% CI) of 1.32 (1.18 to 1.48) for those with hsCRP 2.0 to 4.9 mg/L and 1.40 (1.26 to 1.57) and 2.00 (1.75 to 2.28) for those with hsCRP 5 to 9.9 mg/L and 10 to 15 mg/L, respectively. This relationship was independent of troponin in all suspected ACS patients and was further verified in those who were confirmed to have an ACS diagnosis by clinical coding. The main limitation of our study is that we did not have data on underlying cause of death; however, the exclusion of those with abnormal WCC or hsCRP levels >15 mg/L makes it unlikely that sepsis was a major contributor. CONCLUSIONS: These multicentre, real-world data from a large cohort of patients with suspected ACS suggest that mildly elevated hsCRP (up to 15 mg/L) may be a clinically meaningful prognostic marker beyond troponin and point to its potential utility in selecting patients for novel treatments targeting inflammation. TRIAL REGISTRATION: ClinicalTrials.gov - NCT03507309.
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 1549-1676
dc.sourcenlmid: 101231360
dc.subjectHumans
dc.subjectC-Reactive Protein
dc.subjectMortality
dc.subjectRisk Factors
dc.subjectRetrospective Studies
dc.subjectCohort Studies
dc.subjectLongitudinal Studies
dc.subjectFollow-Up Studies
dc.subjectPredictive Value of Tests
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectAcute Coronary Syndrome
dc.subjectBiomarkers
dc.subjectUnited Kingdom
dc.titleMortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study.
dc.typeArticle
dc.date.updated2022-03-28T19:06:15Z
prism.issueIdentifier2
prism.publicationNamePLoS Med
prism.volume19
dc.identifier.doi10.17863/CAM.82839
dcterms.dateAccepted2022-01-11
rioxxterms.versionofrecord10.1371/journal.pmed.1003911
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidKaura, Amit [0000-0002-6962-3199]
dc.contributor.orcidHartley, Adam [0000-0003-1431-2200]
dc.contributor.orcidPanoulas, Vasileios [0000-0002-9894-9200]
dc.contributor.orcidGlampson, Ben [0000-0002-5601-5581]
dc.contributor.orcidShah, Anoop SV [0000-0002-2825-3419]
dc.contributor.orcidDavies, Jim [0000-0003-4664-6862]
dc.contributor.orcidMulla, Abdulrahim [0000-0002-5943-2348]
dc.contributor.orcidWoods, Kerrie [0000-0001-8106-8290]
dc.contributor.orcidShah, Anoop D [0000-0002-8907-5724]
dc.contributor.orcidElliott, Paul [0000-0002-7511-5684]
dc.contributor.orcidHemmingway, Harry [0000-0003-2279-0624]
dc.contributor.orcidWilliams, Bryan [0000-0002-8094-1841]
dc.contributor.orcidAsselbergs, Folkert W [0000-0002-1692-8669]
dc.contributor.orcidTrickey, Adam [0000-0003-3462-2898]
dc.contributor.orcidFrancis, Darrel P [0000-0002-3410-0814]
dc.contributor.orcidKoenig, Wolfgang [0000-0002-2064-9603]
dc.contributor.orcidShah, Ajay M [0000-0002-6547-0631]
dc.contributor.orcidKharbanda, Rajesh [0000-0002-5356-2395]
dc.contributor.orcidPerera, Divaka [0000-0001-6362-1291]
dc.contributor.orcidMayet, Jamil [0000-0002-4665-6422]
dc.contributor.orcidKhamis, Ramzi [0000-0003-4119-5193]
dc.identifier.eissn1549-1676
pubs.funder-project-idBritish Heart Foundation (FS/14/76/30933, FS/17/16/32560, FS/20/18/34972, CH/1999001/11735, FS/19/17/34172, RE/18/4/34215)
pubs.funder-project-idNational Institute for Health Research (NIHR) (NF-SI-0514-10011, NF-SI-0611-10168, CL-2011-11-003)
pubs.funder-project-idTHIS Institute (PD-2018-01-004)
cam.issuedOnline2022-02-22


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International