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dc.contributor.authorDi Marco Barros, Rafael
dc.contributor.authorFitzpatrick, Zachary
dc.contributor.authorClatworthy, Menna
dc.date.accessioned2022-03-28T19:06:21Z
dc.date.available2022-03-28T19:06:21Z
dc.date.issued2022-03-07
dc.identifier.issn0022-1007
dc.identifier.other35195681
dc.identifier.otherPMC8932540
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335412
dc.descriptionFunder: National Institutes of Health Research Cambridge Biomedical Research Center
dc.description.abstractThe gastrointestinal tract contains trillions of microorganisms that exist symbiotically with the host due to a tolerant, regulatory cell-rich intestinal immune system. However, this intimate relationship with the microbiome inevitably comes with risks, with intestinal organisms being the most common cause of bacteremia. The vasculature of the brain-lining meninges contains fenestrated endothelium, conferring vulnerability to invasion by circulating microbes. We propose that this has evolutionarily led to close links between gut and meningeal immunity, to prime the central nervous system defense against the most likely invaders. This paradigm is exemplified by the dural venous sinus IgA defense system, where the antibody repertoire mirrors that of the gut.
dc.languageeng
dc.publisherRockefeller University Press
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 1540-9538
dc.sourcenlmid: 2985109R
dc.subjectGastrointestinal Tract
dc.subjectMeninges
dc.subjectPlasma Cells
dc.subjectAnimals
dc.subjectHumans
dc.subjectImmunoglobulin A
dc.subjectModels, Immunological
dc.subjectGastrointestinal Microbiome
dc.titleThe gut-meningeal immune axis: Priming brain defense against the most likely invaders.
dc.typeArticle
dc.date.updated2022-03-28T19:06:21Z
prism.issueIdentifier3
prism.publicationNameJ Exp Med
prism.volume219
dc.identifier.doi10.17863/CAM.82841
dcterms.dateAccepted2022-01-26
rioxxterms.versionofrecord10.1084/jem.20211520
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidDi Marco Barros, Rafael [0000-0002-6484-2317]
dc.contributor.orcidClatworthy, Menna [0000-0002-3340-9828]
dc.identifier.eissn1540-9538
pubs.funder-project-idMedical Research Council (MR/S035842/1)
cam.issuedOnline2022-02-23


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International