Early Investigational and Experimental Therapeutics for the Treatment of Hypertriglyceridemia.
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Publication Date
2022-01-25Journal Title
J Cardiovasc Dev Dis
ISSN
2308-3425
Publisher
MDPI AG
Volume
9
Issue
2
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Parthymos, I., Kostapanos, M. S., Liamis, G., & Florentin, M. (2022). Early Investigational and Experimental Therapeutics for the Treatment of Hypertriglyceridemia.. J Cardiovasc Dev Dis, 9 (2) https://doi.org/10.3390/jcdd9020042
Abstract
Hypertriglyceridemia has been identified as a risk factor for cardiovascular disease and acute pancreatitis. To date, there are only few drug classes targeting triglyceride levels such as fibrates and ω-3 fatty acids. These agents are at times insufficient to address very high triglycerides and the residual cardiovascular risk in patients with mixed dyslipidemia. To address this unmet clinical need, novel triglyceride-lowering agents have been in different phases of early clinical development. In this review, the latest and experimental therapies for the management of hypertriglyceridemia are presented. Specifically, ongoing trials evaluating novel apolipoprotein C-III inhibitors, ω-3 fatty acids, as well as fibroblast growth 21 analogues are discussed.
Keywords
Triglycerides, Lipoprotein lipase, Apolipoprotein C-iii, Ω-3 Fatty Acids, Volanesorsen, Fibroblast Growth 21 Factor
Identifiers
35200696, PMC8874974
External DOI: https://doi.org/10.3390/jcdd9020042
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335425
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