Emerging Knowledge of the Neurobiology of COVID-19.
Lim, Mao Fong
Rengasamy, Emma Rachel
Psychiatr Clin North Am
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Butler, M., Cross, B., Hafeez, D., Lim, M. F., Morrin, H., Rengasamy, E. R., Pollak, T., & et al. (2022). Emerging Knowledge of the Neurobiology of COVID-19.. Psychiatr Clin North Am, 45 (1), 29-43. https://doi.org/10.1016/j.psc.2021.11.001
Many patients with COVID-19 will experience acute or longer-term neuropsychiatric complications. The neurobiological mechanisms behind these are beginning to emerge; however, the neurotropic hypothesis is not strongly supported by clinical data. The inflammatory response to SARS-CoV-2 is likely to be responsible for delirium and other common acute neuropsychiatric manifestations. Vascular abnormalities such as endotheliopathies contribute to stroke and cerebral microbleeds, with their attendant neuropsychiatric sequelae. Longer-term neuropsychiatric syndromes fall into 2 broad categories: neuropsychiatric deficits occurring after severe (hospitalized) COVID-19 and "long COVID," which occurs in many patients with a milder acute COVID-19 illness.
Neurobiology, Neuropsychiatry, Delirium, Covid-19, Sars-cov-2, Long Covid, Humans, Nervous System Diseases, COVID-19, SARS-CoV-2
External DOI: https://doi.org/10.1016/j.psc.2021.11.001
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335540