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dc.contributor.authorWang, Jixiong
dc.contributor.authorPatel, Ashish
dc.contributor.authorWason, James MS
dc.contributor.authorNewcombe, Paul J
dc.date.accessioned2022-03-31T20:00:09Z
dc.date.available2022-03-31T20:00:09Z
dc.date.issued2022-03
dc.date.submitted2020-03-09
dc.identifier.issn0006-341X
dc.identifier.otherbiom13424
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335627
dc.description.abstractHigh-dimensional biomarkers such as genomics are increasingly being measured in randomized clinical trials. Consequently, there is a growing interest in developing methods that improve the power to detect biomarker-treatment interactions. We adapt recently proposed two-stage interaction detecting procedures in the setting of randomized clinical trials. We also propose a new stage 1 multivariate screening strategy using ridge regression to account for correlations among biomarkers. For this multivariate screening, we prove the asymptotic between-stage independence, required for familywise error rate control, under biomarker-treatment independence. Simulation results show that in various scenarios, the ridge regression screening procedure can provide substantially greater power than the traditional one-biomarker-at-a-time screening procedure in highly correlated data. We also exemplify our approach in two real clinical trial data applications.
dc.languageen
dc.publisherWiley
dc.subjectBIOMETRIC METHODOLOGY
dc.subjectbiomarker
dc.subjectclinical trial
dc.subjectinteraction
dc.subjectrandomization
dc.subjectridge regression
dc.subjectscreening
dc.titleTwo-stage penalized regression screening to detect biomarker-treatment interactions in randomized clinical trials.
dc.typeArticle
dc.date.updated2022-03-31T20:00:08Z
prism.endingPage150
prism.issueIdentifier1
prism.publicationNameBiometrics
prism.startingPage141
prism.volume78
dc.identifier.doi10.17863/CAM.83058
dcterms.dateAccepted2020-12-31
rioxxterms.versionofrecord10.1111/biom.13424
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidWason, James MS [0000-0002-4691-126X]
dc.contributor.orcidNewcombe, Paul J [0000-0002-5611-6702]
dc.identifier.eissn1541-0420
pubs.funder-project-idMRC (1965771)
cam.issuedOnline2021-01-29


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