Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study
Authors
Montal, Victor
Walpert, Madeleine J
Hong, Young T
Fryer, Tim D
Coles, Jonathan P
Aigbirhio, Franklin I
Hartley, Sigan L
Cohen, Ann D
Tudorascu, Dana L
Christian, Bradley T
Handen, Benjamin L
Klunk, William E
Holland, Anthony J
Zaman, Shahid H
Publication Date
2022-01Journal Title
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
ISSN
2352-8729
Publisher
Wiley
Language
en
Type
Article
This Version
AO
VoR
Metadata
Show full item recordCitation
Padilla, C., Montal, V., Walpert, M. J., Hong, Y. T., Fryer, T. D., Coles, J. P., Aigbirhio, F. I., et al. (2022). Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring https://doi.org/10.1002/dad2.12288
Abstract
Abstract: Introduction: The Down syndrome population has a high prevalence for dementia, often showing their first clinical symptoms in their 40s. Methods: In a longitudinal cohort, we investigate whether amyloid deposition at time point 1 (TP1) could predict cortical thickness change at time point 2 (TP2). The association between tau burden and cortical thickness was also examined at time point 3 (TP3). Results: Between TP1 and TP2 there was pronounced cortical thinning in temporo‐parietal cortices and cortical thickening in the frontal cortex. Baseline amyloid burden was strongly associated to cortical thinning progression, especially in the temporo‐parietal regions. At TP3, tau deposition negatively correlated with cortical atrophy in regions where tau usually accumulates at later Braak stages. Discussion: A higher amount of amyloid accumulation triggers a cascade of changes of disease‐causing processes that eventually lead to dementia. As expected, we found that regions where tau usually accumulates were those also displaying high levels of cortical atrophy.
Keywords
RESEARCH ARTICLE, NEUROIMAGING, Alzheimer's disease, amyloid deposition, cortical atrophy, Down syndrome, longitudinal, tau deposition
Sponsorship
Medical Research Council (98480)
Alzheimer's Research UK (ARUK‐PG2015‐23)
National Institute of Health of the USA (U01AG051406‐01)
Sara Borrell Postdoctoral Fellowship (CD20/00133)
Identifiers
dad212288
External DOI: https://doi.org/10.1002/dad2.12288
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335684
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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