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dc.contributor.authorFoster, Phoebe H
dc.contributor.authorRussell, Lucy L
dc.contributor.authorPeakman, Georgia
dc.contributor.authorConvery, Rhian S
dc.contributor.authorBouzigues, Arabella
dc.contributor.authorGreaves, Caroline V
dc.contributor.authorBocchetta, Martina
dc.contributor.authorCash, David M
dc.contributor.authorvan Swieten, John C
dc.contributor.authorJiskoot, Lize C
dc.contributor.authorMoreno, Fermin
dc.contributor.authorSanchez-Valle, Raquel
dc.contributor.authorLaforce, Robert
dc.contributor.authorGraff, Caroline
dc.contributor.authorMasellis, Mario
dc.contributor.authorTartaglia, Carmela
dc.contributor.authorRowe, James
dc.contributor.authorBorroni, Barbara
dc.contributor.authorFinger, Elizabeth
dc.contributor.authorSynofzik, Matthis
dc.contributor.authorGalimberti, Daniela
dc.contributor.authorVandenberghe, Rik
dc.contributor.authorde Mendonça, Alexandre
dc.contributor.authorButler, Chris R
dc.contributor.authorGerhard, Alex
dc.contributor.authorDucharme, Simon
dc.contributor.authorLe Ber, Isabelle
dc.contributor.authorTagliavini, Fabrizio
dc.contributor.authorSantana, Isabel
dc.contributor.authorPasquier, Florence
dc.contributor.authorLevin, Johannes
dc.contributor.authorDanek, Adrian
dc.contributor.authorOtto, Markus
dc.contributor.authorSorbi, Sandro
dc.contributor.authorRohrer, Jonathan D
dc.contributor.authorGenetic FTD Initiative (GENFI)
dc.date.accessioned2022-04-01T23:30:46Z
dc.date.available2022-04-01T23:30:46Z
dc.date.issued2022-02-09
dc.identifier.issn0010-9452
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335699
dc.description.abstractBACKGROUND: Reduced empathy is a common symptom in frontotemporal dementia (FTD). Although empathy deficits have been extensively researched in sporadic cases, few studies have explored the differences in familial forms of FTD. METHODS: Empathy was examined using a modified version of the Interpersonal Reactivity Index (mIRI) in 676 participants from the Genetic FTD Initiative: 216 mutation-negative controls, 192 C9orf72 expansion carriers, 193 GRN mutation carriers and 75 MAPT mutation carriers. Using global scores from the CDR® plus NACC FTLD, mutation carriers were divided into three groups, asymptomatic (0), very mildly symptomatic/prodromal (.5), or fully symptomatic (1 or more). The mIRI Total score, as well as the subscores of Empathic Concern (EC) and Perspective Taking (PT) were assessed. Linear regression models with bootstrapping were used to assess empathy ratings across genetic groups, as well as across phenotypes in the symptomatic carriers. Neural correlates of empathy deficits were examined using a voxel-based morphometry (VBM) analysis. RESULTS: All fully symptomatic groups scored lower on the mIRI Total, EC, and PT when compared to controls and their asymptomatic or prodromal counterparts (all p < .001). Prodromal C9orf72 expansion carriers also scored significantly lower than controls on the mIRI Total score (p = .046). In the phenotype analysis, all groups (behavioural variant FTD, primary progressive aphasia and FTD with amyotrophic lateral sclerosis) scored significantly lower than controls (all p < .007). VBM revealed an overlapping neural correlate of the mIRI Total score across genetic groups in the orbitofrontal lobe but with additional involvement in the temporal lobe, insula and basal ganglia in both the GRN and MAPT groups, and uniquely more posterior regions such as the parietal lobe and thalamus in the GRN group, and medial temporal structures in the MAPT group. CONCLUSIONS: Significant empathy deficits present in genetic FTD, particularly in symptomatic individuals and those with a bvFTD phenotype, while prodromal deficits are only seen using the mIRI in C9orf72 expansion carriers.
dc.publisherElsevier BV
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectEmpathic concern
dc.subjectEmpathy
dc.subjectFrontotemporal dementia
dc.subjectInterpersonal Reactivity Index
dc.subjectPerspective taking
dc.titleExamining empathy deficits across familial forms of frontotemporal dementia within the GENFI cohort.
dc.typeArticle
dc.publisher.departmentDepartment of Clinical Neurosciences
dc.date.updated2022-04-01T11:50:11Z
prism.endingPage28
prism.publicationDate2022
prism.publicationNameCortex
prism.startingPage12
prism.volume150
dc.identifier.doi10.17863/CAM.83135
dcterms.dateAccepted2022-01-09
rioxxterms.versionofrecord10.1016/j.cortex.2022.01.012
rioxxterms.versionVoR
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.identifier.eissn1973-8102
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_00005/12)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idWellcome Trust (103838/Z/14/Z)
pubs.funder-project-idNational Institute for Health Research (NIHRDH-IS-BRC-1215-20014)
cam.depositDate2022-04-01
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International