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dc.contributor.authorTimmins, Matthew A
dc.contributor.authorRingshausen, Ingo
dc.date.accessioned2022-04-02T01:01:41Z
dc.date.available2022-04-02T01:01:41Z
dc.date.issued2022-03-31
dc.identifier.issn2072-6694
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335701
dc.description.abstractTransforming growth factor-beta (TGFB) is a critical regulator of normal haematopoiesis. Dysregulation of the TGFB pathway is associated with numerous haematological malignancies including myelofibrosis, acute myeloid leukaemia, and lymphoid disorders. TGFB has classically been seen as a negative regulator of proliferation in haematopoiesis whilst stimulating differentiation and apoptosis, as required to maintain homeostasis. Tumours frequently develop intrinsic resistant mechanisms to homeostatic TGFB signalling to antagonise its tumour-suppressive functions. Furthermore, elevated levels of TGFB enhance pathogenesis through modulation of the immune system and tumour microenvironment. Here, we review recent advances in the understanding of TGFB signalling in B-cell malignancies with a focus on the tumour microenvironment. Malignant B-cells harbour subtype-specific alterations in TGFB signalling elements including downregulation of surface receptors, modulation of SMAD signalling proteins, as well as genetic and epigenetic aberrations. Microenvironmental TGFB generates a protumoural niche reprogramming stromal, natural killer (NK), and T-cells. Increasingly, evidence points to complex bi-directional cross-talk between cells of the microenvironment and malignant B-cells. A greater understanding of intercellular communication and the context-specific nature of TGFB signalling may provide further insight into disease pathogenesis and future therapeutic strategies.
dc.languageen
dc.publisherMDPI AG
dc.subjectTGFB
dc.subjectB-cell lymphoma
dc.subjectmicroenvironment
dc.titleTransforming Growth Factor-Beta Orchestrates Tumour and Bystander Cells in B-Cell Non-Hodgkin Lymphoma.
dc.typeArticle
dc.date.updated2022-04-02T01:01:40Z
prism.issueIdentifier7
prism.publicationNameCancers (Basel)
prism.volume14
dc.identifier.doi10.17863/CAM.83137
dcterms.dateAccepted2022-03-23
rioxxterms.versionofrecord10.3390/cancers14071772
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidTimmins, Matthew A [0000-0002-7127-7395]
dc.contributor.orcidRingshausen, Ingo [0000-0002-7247-311X]
dc.identifier.eissn2072-6694
cam.issuedOnline2022-03-31


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