Role of tau deposition in early cognitive decline in Down syndrome.
Hartley, Sigan L
Handen, Benjamin L
Ances, Beau M
Christian, Bradley T
Alzheimers Dement (Amst)
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Hartley, S. L., Handen, B. L., Tudorascu, D., Lee, L., Cohen, A., Piro-Gambetti, B., Zammit, M., et al. (2022). Role of tau deposition in early cognitive decline in Down syndrome.. Alzheimers Dement (Amst) https://doi.org/10.1002/dad2.12256
INTRODUCTION: Drawing on the amyloid/tau/neurodegeneration (AT[N]) model, the study examined whether the tau positron emission tomography (PET) biomarker [18F]AV-1451 was associated with episodic memory problems beyond what was predicted by the amyloid beta (Aβ) PET in Down syndrome (DS). METHODS: Data from 123 non-demented adults with DS (M = 47 years, standard deviation = 6.34) were analyzed. The Cued Recall Test assessed episodic memory. Tau PET standardized update value ratio (SUVR) was assessed across Braak regions as continuous and binary (high tau [TH] vs. low tau [TL]) variable. Global PET Aβ SUVR was assessed as binary variable (Aβ- vs. Aβ+). RESULTS: In models adjusting for controls, tau SUVR was negatively associated with episodic memory performance in the Aβ+ but not Aβ- group. The Aβ+/TH group evidenced significantly worse episodic memory than the Aβ+/TL group. DISCUSSION: Similar to late-onset and autosomal dominant Alzheimer's disease (AD), high tau was an indicator of early prodromal AD in DS.
RESEARCH ARTICLE, NEUROIMAGING, Alzheimer's disease, amyloid, Down syndrome, memory, positron emission tomography, tau
National Institute on Aging (R01AG031110, U01AG051406, U19 AG070043)
National Institute on Child Health and Human Development (U54 HD090256, P50 HD105353)
External DOI: https://doi.org/10.1002/dad2.12256
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335704