Show simple item record

dc.contributor.authorBarnes, Christopher L
dc.contributor.authorBonnéry, Daniel
dc.contributor.authorCardona, Albert
dc.date.accessioned2022-04-04T19:00:12Z
dc.date.available2022-04-04T19:00:12Z
dc.date.issued2022
dc.date.submitted2021-11-25
dc.identifier.issn1932-6203
dc.identifier.otherpone-d-21-37427
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335743
dc.descriptionFunder: Howard Hughes Medical Institute; funder-id: http://dx.doi.org/10.13039/100000011
dc.description.abstractThe pattern of synaptic connections among neurons defines the circuit structure, which constrains the computations that a circuit can perform. The strength of synaptic connections is costly to measure yet important for accurate circuit modeling. Synaptic surface area has been shown to correlate with synaptic strength, yet in the emerging field of connectomics, most studies rely instead on the counts of synaptic contacts between two neurons. Here we quantified the relationship between synaptic count and synaptic area as measured from volume electron microscopy of the larval Drosophila central nervous system. We found that the total synaptic surface area, summed across all synaptic contacts from one presynaptic neuron to a postsynaptic one, can be accurately predicted solely from the number of synaptic contacts, for a variety of neurotransmitters. Our findings support the use of synaptic counts for approximating synaptic strength when modeling neural circuits.
dc.languageen
dc.publisherPublic Library of Science (PLoS)
dc.subjectResearch Article
dc.subjectBiology and life sciences
dc.subjectMedicine and health sciences
dc.subjectResearch and analysis methods
dc.titleSynaptic counts approximate synaptic contact area in Drosophila.
dc.typeArticle
dc.date.updated2022-04-04T19:00:11Z
prism.issueIdentifier4
prism.publicationNamePLoS One
prism.volume17
dc.identifier.doi10.17863/CAM.83180
dcterms.dateAccepted2022-03-12
rioxxterms.versionofrecord10.1371/journal.pone.0266064
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisoreditor: Gilestro, Giorgio F
dc.contributor.orcidBarnes, Christopher L [0000-0002-1296-7310]
dc.contributor.orcidBonnéry, Daniel [0000-0001-8582-7856]
dc.contributor.orcidCardona, Albert [0000-0003-4941-6536]
dc.identifier.eissn1932-6203
cam.issuedOnline2022-04-04


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record