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dc.contributor.authorKachroo, Priyadarshini
dc.contributor.authorStewart, Isobel
dc.contributor.authorKelly, Rachel S
dc.contributor.authorStav, Meryl
dc.contributor.authorMendez, Kevin
dc.contributor.authorDahlin, Amber
dc.contributor.authorSoeteman, Djøra I
dc.contributor.authorChu, Su H
dc.contributor.authorHuang, Mengna
dc.contributor.authorCote, Margaret
dc.contributor.authorKnilhtilä, Hanna M
dc.contributor.authorLee-Sarwar, Kathleen
dc.contributor.authorMcGeachie, Michael
dc.contributor.authorWang, Alberta
dc.contributor.authorWu, Ann Chen
dc.contributor.authorVirkud, Yamini
dc.contributor.authorZhang, Pei
dc.contributor.authorWareham, Nicholas
dc.contributor.authorKarlson, Elizabeth W
dc.contributor.authorWheelock, Craig E
dc.contributor.authorClish, Clary
dc.contributor.authorWeiss, Scott T
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorLasky-Su, Jessica A
dc.date.accessioned2022-04-05T23:30:38Z
dc.date.available2022-04-05T23:30:38Z
dc.date.issued2022-04
dc.identifier.issn1078-8956
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335809
dc.description.abstractThe application of large-scale metabolomic profiling provides new opportunities for realizing the potential of omics-based precision medicine for asthma. By leveraging data from over 14,000 individuals in four distinct cohorts, this study identifies and independently replicates 17 steroid metabolites whose levels were significantly reduced in individuals with prevalent asthma. Although steroid levels were reduced among all asthma cases regardless of medication use, the largest reductions were associated with inhaled corticosteroid (ICS) treatment, as confirmed in a 4-year low-dose ICS clinical trial. Effects of ICS treatment on steroid levels were dose dependent; however, significant reductions also occurred with low-dose ICS treatment. Using information from electronic medical records, we found that cortisol levels were substantially reduced throughout the entire 24-hour daily period in patients with asthma who were treated with ICS compared to those who were untreated and to patients without asthma. Moreover, patients with asthma who were treated with ICS showed significant increases in fatigue and anemia as compared to those without ICS treatment. Adrenal suppression in patients with asthma treated with ICS might, therefore, represent a larger public health problem than previously recognized. Regular cortisol monitoring of patients with asthma treated with ICS is needed to provide the optimal balance between minimizing adverse effects of adrenal suppression while capitalizing on the established benefits of ICS treatment.
dc.description.sponsorshipEffort from PK, JALS and STW is supported by P01HL132825 from the National Heart, Lung and Blood Institute, National Institutes of Health (NIH/NHLBI), USA. IDS is funded by the Medical Research Council (MC_UU_00006/1 - Etiology and Mechanisms). Effort for RK, DIS, MC, KM, MS and JALS is supported by R01HL123915 from the NIH/NHLBI and W81XWH-17-1-0533 from the U.S.A Department of Defense. Effort for RSK is supported by K01HL146980 from the NIH/NHLBI. Effort for SHC is supported by K01HL153941 from the NIH/NHLBI. Effort for MH and JALS is supported by R01HL141826 from the NIH/NHLBI. Effort for AD is supported by K01HL130629 from the NIH/NHLBI. Effort for AD and JALS is supported by 1R01HL152244 from the NIH/NHLBI. Effort for MM and JALS is supported by R01HL155742 from the NIH/NHLBI. Effort for HK is supported by the Jane and Aatos Erkko Foundation, the Paulo Foundation, and the Pediatric Research Foundation. Effort for KLS is supported by K08HL148178 from the NIH/NHLBI. Effort for MM is supported by R01HL139634 from the NIH/NHLBI. Effort for AW is supported by K23HL151819 from the NIH/NHLBI and Thrasher Research Fund Award (15115). Effort for ACW is supported by 1R01HD085993 from the NICHD. Effort for YV is supported by K23AI130408 from the NIAID. Effort for JALS, STW, EWK is supported by the NIH U01HG008685. Effort for PZ and CEW was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant (JP19K21239), the Japanese Environment Research and Technology Development Fund (No. 5-1752), the Gunma University Initiative for Advanced Research (GIAR), the Japan-Sweden Research Cooperative Program between JSPS and STINT (grant no. JPJSBP-1201854), the Swedish Heart Lung Foundation (HLF 20180290, HLF 20200693), and the Swedish Research Council (2016-02798). The EPIC-Norfolk study (https://doi.org/10.22025/2019.10.105.00004) has received funding from the Medical Research Council (MR/N003284/1 MC-UU_12015/1 and MC_UU_00006/1) and Cancer Research UK (C864/A14136). Metabolite measurements in the EPIC-Norfolk study were supported by the MRC Cambridge Initiative in Metabolic Science (MR/L00002/1) and the Innovative Medicines Initiative Joint Undertaking under EMIF grant agreement no. 115372.
dc.format.mediumPrint-Electronic
dc.publisherSpringer Science and Business Media LLC
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleMetabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma.
dc.typeArticle
dc.publisher.departmentMrc Epidemiology Unit
dc.publisher.departmentoffice of The School of Clinical Medicine
dc.date.updated2022-04-05T09:43:54Z
prism.publicationDate2022
prism.publicationNameNat Med
dc.identifier.doi10.17863/CAM.83245
dcterms.dateAccepted2022-01-24
rioxxterms.versionofrecord10.1038/s41591-022-01714-5
rioxxterms.versionAM
dc.contributor.orcidKachroo, Priyadarshini [0000-0002-5807-1333]
dc.contributor.orcidKelly, Rachel S [0000-0003-3023-1822]
dc.contributor.orcidStav, Meryl [0000-0001-6565-3617]
dc.contributor.orcidCote, Margaret [0000-0001-8079-7221]
dc.contributor.orcidLee-Sarwar, Kathleen [0000-0003-0550-1640]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidClish, Clary [0000-0001-8259-9245]
dc.contributor.orcidLangenberg, Claudia [0000-0002-5017-7344]
dc.contributor.orcidLasky-Su, Jessica A [0000-0001-6236-4705]
dc.identifier.eissn1546-170X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMRC (MC_UU_00006/1)
pubs.funder-project-idMedical Research Council (MC_UU_12015/1)
pubs.funder-project-idMedical Research Council (MR/N003284/1)
cam.issuedOnline2022-03-21
cam.orpheus.success2022-04-05 - Embargo set during processing via Fast-track
cam.depositDate2022-04-05
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2022-09-21


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