Clinical Translation of Neutrophil Imaging and Its Role in Cancer.
Authors
Lau, Doreen
Lechermann, Laura M
Gallagher, Ferdia A
Publication Date
2022-04Journal Title
Mol Imaging Biol
ISSN
1536-1632
Publisher
Springer Science and Business Media LLC
Volume
24
Issue
2
Pages
221-234
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Lau, D., Lechermann, L. M., & Gallagher, F. A. (2022). Clinical Translation of Neutrophil Imaging and Its Role in Cancer.. Mol Imaging Biol, 24 (2), 221-234. https://doi.org/10.1007/s11307-021-01649-2
Abstract
Neutrophils are the first line of defense against pathogens and abnormal cells. They regulate many biological processes such as infections and inflammation. Increasing evidence demonstrated a role for neutrophils in cancer, where different subpopulations have been found to possess both pro- or anti-tumorigenic functions in the tumor microenvironment. In this review, we discuss the phenotypic and functional diversity of neutrophils in cancer, their prognostic significance, and therapeutic relevance in human and preclinical models. Molecular imaging methods are increasingly used to probe neutrophil biology in vivo, as well as the cellular changes that occur during tumor progression and over the course of treatment. This review will discuss the role of neutrophil imaging in oncology and the lessons that can be drawn from imaging in infectious diseases and inflammatory disorders. The major factors to be considered when developing imaging techniques and biomarkers for neutrophils in cancer are reviewed. Finally, the potential clinical applications and the limitations of each method are discussed, as well as the challenges for future clinical translation.
Keywords
Review Article, Neutrophils, Cancer, Infection, Inflammation, Imaging, Optical, MRI, SPECT, PET, Immunotherapy
Sponsorship
Cancer Research UK (C12912/A27150)
Cancer Research UK (C96/A25177)
Identifiers
s11307-021-01649-2, 1649
External DOI: https://doi.org/10.1007/s11307-021-01649-2
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335826
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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