Management of asymptomatic severe aortic stenosis: A systematic review and meta-analysis

Abstract

Objectives The management of severe aortic stenosis mandates consideration of aortic valve intervention for symptomatic patients. However, for asymptomatic patients with severe aortic stenosis recent randomised trials supported earlier intervention. We conducted a systematic review and meta-analysis to evaluate all the available data comparing the two management strategies. Methods PubMed, Cochrane and Web of Science databases were systematically searched from inception until January 10th 2022. The search key terms were “asymptomatic”, “severe aortic stenosis” and “intervention”. Results Meta-analysis of the two published randomised trials, AVATAR and RECOVERY, included 302 patients and showed that early intervention resulted in 55% reduction in all-cause mortality (HR= 0.45, 95%CI: 0.24, 0.86; I2 0%) and 79% reduction of the risk of hospitalisation for heart failure (HR= 0.21, 95%CI: 0.05, 0.96; I2 15%). There was no difference in the risk of cardiovascular death between the two groups (HR= 0.36, 95%CI: 0.03, 3.78; I2 78%). Additionally, meta-analysis of eight observational studies showed improved mortality in patients treated with early intervention (HR= 0.38, 95%CI: 0.26, 0.56; I2 77%). Conclusion This meta-analysis provides evidence that in patients with severe asymptomatic aortic stenosis, early intervention reduces all-cause mortality and improves outcomes compared to conservative management. Whilst this is very encouraging, further randomised controlled studies are needed to draw firm conclusions and identify the optimal timing of intervention.