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dc.contributor.authorZhang, Joyce
dc.contributor.authorMeiser-Stedman, Richard
dc.contributor.authorJones, Bobby
dc.contributor.authorSmith, Patrick
dc.contributor.authorDalgleish, Tim
dc.contributor.authorBoyle, Adrian
dc.contributor.authorEdwards, Andrea
dc.contributor.authorSubramanyam, Devasena
dc.contributor.authorDixon, Clare
dc.contributor.authorSinclaire-Harding, Lysandra
dc.contributor.authorSchweizer, Susanne
dc.contributor.authorNewby, Jill
dc.contributor.authorMcKinnon, Anna
dc.date.accessioned2022-04-07T01:02:46Z
dc.date.available2022-04-07T01:02:46Z
dc.date.issued2022
dc.identifier.issn2000-8198
dc.identifier.other35251531
dc.identifier.otherPMC8890561
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335856
dc.description.abstractOBJECTIVE: Post-traumatic stress disorder and depression have high comorbidity. Understanding their relationship is of clinical and theoretical importance. A comprehensive way to understand post-trauma psychopathology is through symptom trajectories. This study aims to look at the developmental courses of PTSD and depression symptoms and their interrelationship in the initial months post-trauma in children and adolescents. METHODS: Two-hundred-and-seventeen children and adolescents aged between eight and 17 exposed to single-event trauma were included in the study. Post-traumatic stress symptoms (PTSS) and depression symptoms were measured at 2 weeks, 2 months and 9 months, with further psychological variables measured at the 2-week assessment. Group-based trajectory modelling (GBTM) was applied to estimate the latent developmental clusters of the two outcomes. Logistic regression was used to identify predictors associated with high symptom groups. RESULTS: The GBTM yielded a three-group model for PTSS and a three-group model for depression. PTSS trajectories showed symptoms reduced to a non-clinical level by 9 months for all participants (if they were not already in the non-clinical range): participants were observed to be resilient (42.4%) or recovered within 2 months (35.6%), while 21.9% experienced high level PTSS but recovered by 9 months post-trauma. The depression symptom trajectories predicted a chronic non-recovery group (20.1%) and two mild symptom groups (45.9%, 34.0%). Further analysis showed high synchronicity between PTSS and depression groups. Peri-event panic, negative appraisals, rumination and thought suppression at 2 weeks predicted slow recovery from PTSS. Pre-trauma wellbeing, post-trauma anxiety and negative appraisals predicted chronic depression. CONCLUSIONS: Post-trauma depression was more persistent than PTSS at 9 months in the sampled population. Cognitive appraisal was the shared risk factor to high symptom groups of both PTSS and depression.
dc.languageeng
dc.publisherInforma UK Limited
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourcenlmid: 101559025
dc.sourceessn: 2000-8066
dc.subjectDepression
dc.subjectComorbidity
dc.subjectTrajectory
dc.subjectPtsd
dc.subjectLcga
dc.subjectComputational Phenotyping
dc.subjectGbtm
dc.titleTrajectory of post-traumatic stress and depression among children and adolescents following single-incident trauma.
dc.typeArticle
dc.date.updated2022-04-07T01:02:46Z
prism.issueIdentifier1
prism.publicationNameEur J Psychotraumatol
prism.volume13
dc.identifier.doi10.17863/CAM.83289
rioxxterms.versionofrecord10.1080/20008198.2022.2037906
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.contributor.orcidZhang, Joyce [0000-0001-5028-584X]
dc.contributor.orcidMeiser-Stedman, Richard [0000-0002-0262-623X]
dc.contributor.orcidNewby, Jill [0000-0002-6473-9811]
dc.identifier.eissn2000-8066
pubs.funder-project-idMRC (unknown)
pubs.funder-project-idMedical Research Council (MC_UU_00005/4)
cam.issuedOnline2022-02-28


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International