Different inflammatory blood markers correlate with specific outcomes in incident HPV-negative head and neck squamous cell carcinoma: a retrospective cohort study.
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Authors
Boscolo-Rizzo, Paolo
D'Alessandro, Andrea
Borsetto, Daniele
Tofanelli, Margherita
Deganello, Alberto
Tomasoni, Michele
Nicolai, Piero
Bossi, Paolo
Spinato, Giacomo
Menegaldo, Anna
Ciorba, Andrea
Pelucchi, Stefano
Bianchini, Chiara
Cazzador, Diego
Ramaciotti, Giulia
Lupato, Valentina
Giacomarra, Vittorio
Molteni, Gabriele
Marchioni, Daniele
Fabbris, Cristoforo
Occhini, Antonio
Bertino, Giulia
Fussey, Jonathan
Tirelli, Giancarlo
Publication Date
2022-03-05Journal Title
BMC Cancer
ISSN
1471-2407
Publisher
Springer Science and Business Media LLC
Volume
22
Issue
1
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Boscolo-Rizzo, P., D'Alessandro, A., Polesel, J., Borsetto, D., Tofanelli, M., Deganello, A., Tomasoni, M., et al. (2022). Different inflammatory blood markers correlate with specific outcomes in incident HPV-negative head and neck squamous cell carcinoma: a retrospective cohort study.. BMC Cancer, 22 (1) https://doi.org/10.1186/s12885-022-09327-4
Abstract
BACKGROUND: Inflammatory blood markers have been associated with oncological outcomes in several cancers, but evidence for head and neck squamous cell carcinoma (HNSCC) is scanty. Therefore, this study aims at investigating the association between five different inflammatory blood markers and several oncological outcomes. METHODS: This multi-centre retrospective analysis included 925 consecutive patients with primary HPV-negative HNSCC (median age: 68 years) diagnosed between April 2004 and June 2018, whose pre-treatment blood parameters were available. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), systemic inflammatory marker (SIM), and systemic immune-inflammation index (SII) were calculated; their associations with local, regional, and distant failure, disease-free survival (DFS), and overall survival (OS) was calculated. RESULTS: The median follow-up was 53 months. All five indexes were significantly associated with OS; the highest accuracy in predicting patients' survival was found for SIM (10-year OS = 53.2% for SIM < 1.40 and 40.9% for SIM ≥ 2.46; c-index = 0.569) and LMR (10-year OS = 60.4% for LMR ≥ 3.76 and 40.5% for LMR < 2.92; c-index = 0.568). While LMR showed the strongest association with local failure (HR = 2.16; 95% CI:1.22-3.84), PLR showed the strongest association with regional (HR = 1.98; 95% CI:1.24-3.15) and distant failure (HR = 1.67; 95% CI:1.08-2.58). CONCLUSION: Different inflammatory blood markers may be useful to identify patients at risk of local, regional, or distant recurrences who may benefit from treatment intensification or intensive surveillance programs.
Keywords
Head And Neck Cancer, Overall Survival, Local Recurrence, Blood Markers, Inflammatory System, Humans, Head and Neck Neoplasms, Inflammation Mediators, Blood Cell Count, Health Status Indicators, Risk Assessment, Retrospective Studies, Aged, Middle Aged, Female, Male, Biomarkers, Tumor, Squamous Cell Carcinoma of Head and Neck
Identifiers
35248020, PMC8897882
External DOI: https://doi.org/10.1186/s12885-022-09327-4
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335858
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