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dc.contributor.authorMaslove, David M
dc.contributor.authorTang, Benjamin
dc.contributor.authorShankar-Hari, Manu
dc.contributor.authorLawler, Patrick R
dc.contributor.authorAngus, Derek C
dc.contributor.authorBaillie, J Kenneth
dc.contributor.authorBaron, Rebecca M
dc.contributor.authorBauer, Michael
dc.contributor.authorBuchman, Timothy G
dc.contributor.authorCalfee, Carolyn S
dc.contributor.authorDos Santos, Claudia C
dc.contributor.authorGiamarellos-Bourboulis, Evangelos J
dc.contributor.authorGordon, Anthony C
dc.contributor.authorKellum, John A
dc.contributor.authorKnight, Julian C
dc.contributor.authorLeligdowicz, Aleksandra
dc.contributor.authorMcAuley, Daniel F
dc.contributor.authorMcLean, Anthony S
dc.contributor.authorMenon, David
dc.contributor.authorMeyer, Nuala J
dc.contributor.authorMoldawer, Lyle L
dc.contributor.authorReddy, Kiran
dc.contributor.authorReilly, John P
dc.contributor.authorRussell, James A
dc.contributor.authorSevransky, Jonathan E
dc.contributor.authorSeymour, Christopher W
dc.contributor.authorShapiro, Nathan I
dc.contributor.authorSinger, Mervyn
dc.contributor.authorSummers, Charlotte
dc.contributor.authorSweeney, Timothy E
dc.contributor.authorThompson, B Taylor
dc.contributor.authorvan der Poll, Tom
dc.contributor.authorVenkatesh, Balasubramanian
dc.contributor.authorWalley, Keith R
dc.contributor.authorWalsh, Timothy S
dc.contributor.authorWare, Lorraine B
dc.contributor.authorWong, Hector R
dc.contributor.authorZador, Zsolt E
dc.contributor.authorMarshall, John C
dc.date.accessioned2022-04-11T23:30:37Z
dc.date.available2022-04-11T23:30:37Z
dc.date.issued2022-06
dc.identifier.issn1078-8956
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335996
dc.description.abstractResearch and practice in critical care medicine have long been defined by syndromes, which, despite being clinically recognizable entities, are, in fact, loose amalgams of heterogeneous states that may respond differently to therapy. Mounting translational evidence-supported by research on respiratory failure due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-suggests that the current syndrome-based framework of critical illness should be reconsidered. Here we discuss recent findings from basic science and clinical research in critical care and explore how these might inform a new conceptual model of critical illness. De-emphasizing syndromes, we focus on the underlying biological changes that underpin critical illness states and that may be amenable to treatment. We hypothesize that such an approach will accelerate critical care research, leading to a richer understanding of the pathobiology of critical illness and of the key determinants of patient outcomes. This, in turn, will support the design of more effective clinical trials and inform a more precise and more effective practice at the bedside.
dc.publisherSpringer Science and Business Media LLC
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleRedefining critical illness.
dc.typeArticle
dc.publisher.departmentDepartment of Medicine
dc.date.updated2022-04-08T15:00:04Z
prism.publicationNameNat Med
dc.identifier.doi10.17863/CAM.83428
dcterms.dateAccepted2022-04-28
rioxxterms.versionofrecord10.1038/s41591-022-01843-x
rioxxterms.versionAM
dc.contributor.orcidMaslove, David M [0000-0002-0765-7158]
dc.contributor.orcidTang, Benjamin [0000-0002-1469-9540]
dc.contributor.orcidShankar-Hari, Manu [0000-0002-5338-2538]
dc.contributor.orcidBaillie, J Kenneth [0000-0001-5258-793X]
dc.contributor.orcidBauer, Michael [0000-0002-1521-3514]
dc.contributor.orcidBuchman, Timothy G [0000-0001-7350-5921]
dc.contributor.orcidGiamarellos-Bourboulis, Evangelos J [0000-0003-4713-3911]
dc.contributor.orcidGordon, Anthony C [0000-0002-0419-547X]
dc.contributor.orcidKellum, John A [0000-0003-1995-2653]
dc.contributor.orcidLeligdowicz, Aleksandra [0000-0001-6055-4644]
dc.contributor.orcidMcAuley, Daniel F [0000-0002-3283-1947]
dc.contributor.orcidMenon, David [0000-0002-3228-9692]
dc.contributor.orcidMeyer, Nuala J [0000-0003-4597-5584]
dc.contributor.orcidReddy, Kiran [0000-0002-1621-1481]
dc.contributor.orcidReilly, John P [0000-0003-3937-5320]
dc.contributor.orcidSinger, Mervyn [0000-0002-1042-6350]
dc.contributor.orcidSummers, Charlotte [0000-0002-7269-2873]
dc.contributor.orcidvan der Poll, Tom [0000-0002-9199-5079]
dc.contributor.orcidWong, Hector R [0000-0001-7989-1173]
dc.identifier.eissn1546-170X
rioxxterms.typeJournal Article/Review
cam.issuedOnline2022-06-17
cam.orpheus.successTue Jun 21 09:20:59 BST 2022 - Embargo updated
cam.orpheus.counter5
cam.depositDate2022-04-08
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2022-12-30


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