Lipid metabolism after mild cold stress in persons with a cervical spinal cord injury
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Authors
Nishiyama, Kazunari
Kamijo, Yoshi-Ichiro
Kinoshita, Tokio
Goosey-Tolfrey, Victoria
Hoekstra, Sven
Nishimura, Yukihide
Kawasaki, Takashi
Ogawa, Takahiro
Tajima, Fumihiro
Publication Date
2022-11Journal Title
Spinal Cord
ISSN
1362-4393
Publisher
Springer Nature [academic journals on nature.com]
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Nishiyama, K., Kamijo, Y., van der Scheer, J., Kinoshita, T., Goosey-Tolfrey, V., Hoekstra, S., Nishimura, Y., et al. (2022). Lipid metabolism after mild cold stress in persons with a cervical spinal cord injury. Spinal Cord https://doi.org/10.1038/s41393-022-00788-9
Abstract
22 ABSTRACT
23 Study design Experimental study
24 Objectives To compare lipid metabolism in individuals with a cervical spinal cord injury (SCIC)
25 and able-bodied (AB) persons in response to mild cold stress.
26 Settings Laboratory of Wakayama Medical University, Japan.
27 Methods Nine males with SCIC and 11 AB wore a water-perfusion suit in a supine position.
28 Following 30-min rest thermoneutrality, the whole body was cooled by perfusing 25°C water
29 through the suit for 15-20 minutes (CS). Blood samples were collected before, immediately, and 60
30 (post-CS60) and 120 minutes after CS (post-CS120). Concentrations of serum free fatty acid
31 ([FFA]s), total ketone bodies ([tKB]s), insulin ([Ins]s) and plasma adrenaline ([Ad]p), noradrenaline
32 ([NA]p) and glucose ([Glc]p) were assessed.
33 Results [Ad]p in SCIC were lower than AB throughout the study (p=0.0002) and remained largely
34 unchanged in both groups. [NA]p increased after cold stress in AB only (p<0.0001; GxT p=0.006).
35 [FFA]s increased by 62% immediately after cold stress in SCIC (p=0.0028), without a difference
36 between groups (p=0.65). [tKB]s increased by 69% at post-CS60 and 132% at post-CS120 from the
37 start in SCIC with no differences between groups (p=0.54). [Glc]p and [Ins]s were reduced in SCIc
38 only (GxT p=0.003 and p=0.001, respectively).
39 Conclusion These data indicate that mild cold stress acutely elevates lipid and ketone body
40 metabolism in persons with SCIc, despite the presence of sympathetic dysfunction.
Identifiers
External DOI: https://doi.org/10.1038/s41393-022-00788-9
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336075
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