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dc.contributor.authorWestwater, Margaret L
dc.contributor.authorMurley, Alexander
dc.contributor.authorDiederen, Kelly MJ
dc.contributor.authorCarpenter, T Adrian
dc.contributor.authorZiauddeen, Hisham
dc.contributor.authorFletcher, Paul
dc.date.accessioned2022-04-19T13:17:17Z
dc.date.available2022-04-19T13:17:17Z
dc.date.issued2022-03-15
dc.identifier.issn2158-3188
dc.identifier.other35292626
dc.identifier.otherPMC8924163
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/336161
dc.descriptionFunder: Cambridge Overseas Trust
dc.descriptionFunder: Bernard Wolfe Health Neuroscience Fund
dc.descriptionFunder: Holt Fellowship
dc.descriptionFunder: NIH Oxford Cambridge Scholars Program
dc.description.abstractAnorexia nervosa (AN) and bulimia nervosa (BN) are associated with altered brain structure and function, as well as increased habitual behavior. This neurobehavioral profile may implicate neurochemical changes in the pathogenesis of these illnesses. Altered glutamate, myo-inositol and N-acetyl aspartate (NAA) concentrations are reported in restrictive AN, yet whether these extend to binge-eating disorders, or relate to habitual traits in affected individuals, remains unknown. We therefore used single-voxel proton magnetic resonance spectroscopy to measure glutamate, myo-inositol, and NAA in the right inferior lateral prefrontal cortex and the right occipital cortex of 85 women [n = 22 AN (binge-eating/purging subtype; AN-BP), n = 33 BN, n = 30 controls]. To index habitual behavior, participants performed an instrumental learning task and completed the Creature of Habit Scale. Women with AN-BP, but not BN, had reduced myo-inositol and NAA concentrations relative to controls in both regions. Although patient groups had intact instrumental learning task performance, both groups reported increased routine behaviors compared to controls, and automaticity was related to reduced prefrontal glutamate and NAA participants with AN-BP. Our findings extend previous reports of reduced myo-inositol and NAA levels in restrictive AN to AN-BP, which may reflect disrupted axonal-glial signaling. Although we found inconsistent support for increased habitual behavior in AN-BP and BN, we identified preliminary associations between prefrontal metabolites and automaticity in AN-BP. These results provide further evidence of unique neurobiological profiles across binge-eating disorders.
dc.description.sponsorshipBernard Wolfe Health Neuroscience Fund
dc.languageeng
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101562664
dc.sourceessn: 2158-3188
dc.subjectBrain
dc.subjectHumans
dc.subjectAnorexia
dc.subjectAnorexia Nervosa
dc.subjectBulimia
dc.subjectFemale
dc.subjectBulimia Nervosa
dc.titleCharacterizing cerebral metabolite profiles in anorexia and bulimia nervosa and their associations with habitual behavior.
dc.typeArticle
dc.date.updated2022-04-19T13:17:16Z
prism.issueIdentifier1
prism.publicationNameTransl Psychiatry
prism.volume12
dc.identifier.doi10.17863/CAM.83586
dcterms.dateAccepted2022-02-24
rioxxterms.versionofrecord10.1038/s41398-022-01872-7
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidWestwater, Margaret L [0000-0002-2918-0979]
dc.contributor.orcidMurley, Alexander [0000-0003-0813-0670]
dc.contributor.orcidZiauddeen, Hisham [0000-0003-4044-1719]
dc.contributor.orcidFletcher, Paul [0000-0001-8257-1517]
dc.identifier.eissn2158-3188
pubs.funder-project-idWellcome Trust (206368/Z/17/Z)
pubs.funder-project-idWellcome Trust (100574/B/12/Z)
pubs.funder-project-idNational Institute for Health Research (NIHRDH-IS-BRC-1215-20014)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International