Show simple item record

dc.contributor.authorSpina, Elena
dc.contributor.authorSimundza, Julia
dc.contributor.authorIncassati, Angela
dc.contributor.authorChandramouli, Anupama
dc.contributor.authorKugler, Matthias C
dc.contributor.authorLin, Ziyan
dc.contributor.authorKhodadadi-Jamayran, Alireza
dc.contributor.authorWatson, Christine J
dc.contributor.authorCowin, Pamela
dc.date.accessioned2022-04-19T13:18:14Z
dc.date.available2022-04-19T13:18:14Z
dc.date.issued2022-03-17
dc.identifier.issn2041-1723
dc.identifier.other35302059
dc.identifier.otherPMC8931046
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/336181
dc.descriptionFunder: Will-Rogers and the Stony Wold-Herbert Foundation
dc.descriptionFunder: NYC Peter Rowley award C02857
dc.descriptionFunder: The Susan G Komen Foundation For The Cure
dc.description.abstractGpr125 is an orphan G-protein coupled receptor, with homology to cell adhesion and axonal guidance factors, that is implicated in planar polarity and control of cell movements. By lineage tracing we demonstrate that Gpr125 is a highly specific marker of bipotent mammary stem cells in the embryo and of multiple long-lived unipotent basal mammary progenitors in perinatal and postnatal glands. Nipple-proximal Gpr125+ cells express a transcriptomic profile indicative of chemo-repulsion and cell movement, whereas Gpr125+ cells concentrated at invasive ductal tips display a hybrid epithelial-mesenchymal phenotype and are equipped to bind chemokine and growth factors and secrete a promigratory matrix. Gpr125 progenitors acquire bipotency in the context of transplantation and cancer and are greatly expanded and massed at the pushing margins of short latency MMTV-Wnt1 tumors. High Gpr125 expression identifies patients with particularly poor outcome within the basal breast cancer subtype highlighting its potential utility as a factor to stratify risk.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101528555
dc.sourceessn: 2041-1723
dc.subjectMammary Glands, Animal
dc.subjectStem Cells
dc.subjectAnimals
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectMammary Neoplasms, Experimental
dc.subjectCell Movement
dc.subjectFemale
dc.titleGpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency.
dc.typeArticle
dc.date.updated2022-04-19T13:18:13Z
prism.issueIdentifier1
prism.publicationNameNat Commun
prism.volume13
dc.identifier.doi10.17863/CAM.83606
dcterms.dateAccepted2022-02-16
rioxxterms.versionofrecord10.1038/s41467-022-28937-x
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidSpina, Elena [0000-0002-0838-9466]
dc.contributor.orcidKugler, Matthias C [0000-0002-8587-6129]
dc.contributor.orcidWatson, Christine J [0000-0002-8548-5902]
dc.contributor.orcidCowin, Pamela [0000-0002-1827-1154]
dc.identifier.eissn2041-1723
pubs.funder-project-idNHLBI NIH HHS (R56 HL151700)
pubs.funder-project-idNIH HHS (S10 OD021747)
pubs.funder-project-idNCI NIH HHS (T32 CA009161, P30 CA016087, R21 CA129905)
pubs.funder-project-idU.S. Department of Health &amp (T32GM066704)
pubs.funder-project-idU.S. Department of Defense (United States Department of Defense) (W81XWH-17-1-0013 BC160959)
pubs.funder-project-idU.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) (R56-HL151700)
pubs.funder-project-idU.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) (T32CA009161-44, NIH-R21-CA129905)
pubs.funder-project-idU.S. Department of Health &amp (T32CA009161-44, NIH-R21-CA129905)
pubs.funder-project-idU.S. Department of Health &amp (R56-HL151700)
pubs.funder-project-idNIGMS NIH HHS (T32 GM066704)
pubs.funder-project-idU.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) (T32GM066704)
pubs.funder-project-idU.S. Department of Defense (W81XWH-17-1-0013 BC160959)
cam.issuedOnline2022-03-17


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International