GBAand ApoEimpact cognitive decline in Parkinson’s disease: a 10-year population-based study

Abstract

Patients with Parkinson’s disease (PD) are more likely to experience cognitive decline than healthy older adults. 1 Problems with cognition affect patients’ ability to work and function independently, placing them at higher risk of poor quality of life and nursing home placement.2 The evolution of cognitive symptoms in PD is very heterogeneous1 and impedes the recruitment of relevant participants into clinical trials. Hence, the means to identify patients at high risk of cognitive deficits would significantly improve the design and costs of future trials