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dc.contributor.authorCarruthers, Vickyanne
dc.contributor.authorBarnett, Shelby
dc.contributor.authorRees, Rebecca
dc.contributor.authorArif, Tasnim
dc.contributor.authorSlater, Olga
dc.contributor.authorRamanujachar, Ramya
dc.contributor.authorJohnson, Katie
dc.contributor.authorBrown, Sarah
dc.contributor.authorGraham, Catherine
dc.contributor.authorBurke, GA Amos
dc.contributor.authorVeal, Gareth J
dc.date.accessioned2022-04-20T09:00:17Z
dc.date.available2022-04-20T09:00:17Z
dc.date.issued2022-07
dc.date.submitted2022-02-15
dc.identifier.issn1545-5009
dc.identifier.otherpbc29722
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/336254
dc.description.abstractInfantile myofibroma is a rare, benign tumour of infancy typically managed surgically. In a minority of cases, more aggressive disease is seen and chemotherapy with vinblastine and methotrexate may be used, although evidence for this is limited. Chemotherapy dosing in infants is challenging, and vinblastine disposition in infants is unknown. We describe the use of vinblastine therapeutic drug monitoring in four cases of infantile myofibroma. Marked inter- and intrapatient variability was observed, highlighting the poorly understood pharmacokinetics of vinblastine in children, the challenges inherent in treating neonates, and the role of adaptive dosing in optimising drug exposure in challenging situations.
dc.languageen
dc.publisherWiley
dc.subjectONCOLOGY: BRIEF REPORT
dc.subjectinfantile myofibroma
dc.subjectneonate
dc.subjectpharmacokinetics
dc.subjecttherapeutic drug monitoring
dc.subjectvinblastine
dc.titleClinical utility of vinblastine therapeutic drug monitoring for the treatment of infantile myofibroma patients: A case series.
dc.typeArticle
dc.date.updated2022-04-20T09:00:16Z
prism.publicationNamePediatr Blood Cancer
dc.identifier.doi10.17863/CAM.83673
dcterms.dateAccepted2022-03-15
rioxxterms.versionofrecord10.1002/pbc.29722
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidVeal, Gareth J [0000-0002-1897-8678]
dc.identifier.eissn1545-5017
cam.issuedOnline2022-04-20


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