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dc.contributor.authorBethlehem, RAI
dc.contributor.authorSeidlitz, J
dc.contributor.authorWhite, Simon
dc.contributor.authorVogel, JW
dc.contributor.authorAnderson, KM
dc.contributor.authorAdamson, C
dc.contributor.authorAdler, S
dc.contributor.authorAlexopoulos, GS
dc.contributor.authorAnagnostou, E
dc.contributor.authorAreces-Gonzalez, A
dc.contributor.authorAstle, DE
dc.contributor.authorAuyeung, B
dc.contributor.authorAyub, M
dc.contributor.authorBae, J
dc.contributor.authorBall, G
dc.contributor.authorBaron-Cohen, S
dc.contributor.authorBeare, R
dc.contributor.authorBedford, SA
dc.contributor.authorBenegal, V
dc.contributor.authorBeyer, F
dc.contributor.authorBlangero, J
dc.contributor.authorBlesa Cábez, M
dc.contributor.authorBoardman, JP
dc.contributor.authorBorzage, M
dc.contributor.authorBosch-Bayard, JF
dc.contributor.authorBourke, N
dc.contributor.authorCalhoun, VD
dc.contributor.authorChakravarty, MM
dc.contributor.authorChen, C
dc.contributor.authorChertavian, C
dc.contributor.authorChetelat, G
dc.contributor.authorChong, YS
dc.contributor.authorCole, JH
dc.contributor.authorCorvin, A
dc.contributor.authorCostantino, M
dc.contributor.authorCourchesne, E
dc.contributor.authorCrivello, F
dc.contributor.authorCropley, VL
dc.contributor.authorCrosbie, J
dc.contributor.authorCrossley, N
dc.contributor.authorDelarue, M
dc.contributor.authorDelorme, R
dc.contributor.authorDesrivieres, S
dc.contributor.authorDevenyi, GA
dc.contributor.authorDi Biase, MA
dc.contributor.authorDolan, R
dc.contributor.authorDonald, KA
dc.contributor.authorDonohoe, G
dc.contributor.authorDunlop, K
dc.contributor.authorEdwards, AD
dc.contributor.authorElison, JT
dc.contributor.authorEllis, CT
dc.contributor.authorElman, JA
dc.contributor.authorEyler, L
dc.contributor.authorFair, DA
dc.contributor.authorFeczko, E
dc.contributor.authorFletcher, PC
dc.contributor.authorFonagy, P
dc.contributor.authorFranz, CE
dc.contributor.authorGalan-Garcia, L
dc.contributor.authorGholipour, A
dc.contributor.authorGiedd, J
dc.contributor.authorGilmore, JH
dc.contributor.authorGlahn, DC
dc.contributor.authorGoodyer, IM
dc.contributor.authorGrant, PE
dc.contributor.authorGroenewold, NA
dc.contributor.authorGunning, FM
dc.contributor.authorGur, RE
dc.contributor.authorGur, RC
dc.contributor.authorHammill, CF
dc.contributor.authorHansson, O
dc.contributor.authorHedden, T
dc.contributor.authorHeinz, A
dc.contributor.authorHenson, RN
dc.contributor.authorHeuer, K
dc.contributor.authorHoare, J
dc.contributor.authorHolla, B
dc.contributor.authorHolmes, AJ
dc.contributor.authorHolt, R
dc.contributor.authorHuang, H
dc.contributor.authorIm, K
dc.contributor.authorIpser, J
dc.contributor.authorJack, CR
dc.contributor.authorJackowski, AP
dc.contributor.authorJia, T
dc.contributor.authorJohnson, KA
dc.contributor.authorJones, PB
dc.contributor.authorJones, DT
dc.contributor.authorKahn, RS
dc.contributor.authorKarlsson, H
dc.contributor.authorKarlsson, L
dc.contributor.authorKawashima, R
dc.contributor.authorKelley, EA
dc.contributor.authorKern, S
dc.contributor.authorKim, KW
dc.contributor.authorKitzbichler, MG
dc.contributor.authorKremen, WS
dc.contributor.authorLalonde, F
dc.contributor.authorLandeau, B
dc.contributor.authorLee, S
dc.contributor.authorLerch, J
dc.contributor.authorLewis, JD
dc.contributor.authorLi, J
dc.contributor.authorLiao, W
dc.contributor.authorListon, C
dc.contributor.authorLombardo, MV
dc.contributor.authorLv, J
dc.contributor.authorLynch, C
dc.contributor.authorMallard, TT
dc.contributor.authorMarcelis, M
dc.contributor.authorMarkello, RD
dc.contributor.authorMathias, SR
dc.contributor.authorMazoyer, B
dc.contributor.authorMcGuire, P
dc.contributor.authorMeaney, MJ
dc.contributor.authorMechelli, A
dc.contributor.authorMedic, N
dc.contributor.authorMisic, B
dc.contributor.authorMorgan, SE
dc.contributor.authorMothersill, D
dc.contributor.authorNigg, J
dc.contributor.authorOng, MQW
dc.contributor.authorOrtinau, C
dc.contributor.authorOssenkoppele, R
dc.contributor.authorOuyang, M
dc.contributor.authorPalaniyappan, L
dc.contributor.authorPaly, L
dc.contributor.authorPan, PM
dc.contributor.authorPantelis, C
dc.contributor.authorPark, MM
dc.contributor.authorPaus, T
dc.contributor.authorPausova, Z
dc.contributor.authorPaz-Linares, D
dc.contributor.authorPichet Binette, A
dc.contributor.authorPierce, K
dc.contributor.authorQian, X
dc.contributor.authorQiu, J
dc.contributor.authorQiu, A
dc.contributor.authorRaznahan, A
dc.contributor.authorRittman, T
dc.contributor.authorRodrigue, A
dc.contributor.authorRollins, CK
dc.contributor.authorRomero-Garcia, R
dc.contributor.authorRonan, L
dc.contributor.authorRosenberg, MD
dc.contributor.authorRowitch, David
dc.contributor.authorSalum, GA
dc.contributor.authorSatterthwaite, TD
dc.contributor.authorSchaare, HL
dc.contributor.authorSchachar, RJ
dc.contributor.authorSchultz, AP
dc.contributor.authorSchumann, G
dc.contributor.authorSchöll, M
dc.contributor.authorSharp, D
dc.contributor.authorShinohara, RT
dc.contributor.authorSkoog, I
dc.contributor.authorSmyser, CD
dc.contributor.authorSperling, RA
dc.contributor.authorStein, DJ
dc.contributor.authorStolicyn, A
dc.contributor.authorSuckling, J
dc.contributor.authorSullivan, G
dc.contributor.authorTaki, Y
dc.contributor.authorThyreau, B
dc.contributor.authorToro, R
dc.contributor.authorTraut, N
dc.contributor.authorTsvetanov, KA
dc.contributor.authorTurk-Browne, NB
dc.contributor.authorTuulari, JJ
dc.contributor.authorTzourio, C
dc.contributor.authorVachon-Presseau, É
dc.contributor.authorValdes-Sosa, MJ
dc.contributor.authorValdes-Sosa, PA
dc.contributor.authorValk, SL
dc.contributor.authorvan Amelsvoort, T
dc.contributor.authorVandekar, SN
dc.contributor.authorVasung, L
dc.contributor.authorVictoria, LW
dc.contributor.authorVilleneuve, S
dc.contributor.authorVillringer, A
dc.contributor.authorVértes, PE
dc.contributor.authorWagstyl, K
dc.contributor.authorWang, YS
dc.contributor.authorWarfield, SK
dc.contributor.authorWarrier, V
dc.contributor.authorWestman, E
dc.contributor.authorWestwater, ML
dc.contributor.authorWhalley, HC
dc.contributor.authorWitte, AV
dc.contributor.authorYang, N
dc.contributor.authorYeo, B
dc.contributor.authorYun, H
dc.contributor.authorZalesky, A
dc.contributor.authorZar, HJ
dc.contributor.authorZettergren, A
dc.contributor.authorZhou, JH
dc.contributor.authorZiauddeen, H
dc.contributor.authorZugman, A
dc.contributor.authorZuo, XN
dc.contributor.author3R-BRAIN
dc.contributor.authorAIBL
dc.contributor.authorAlzheimer’s Disease Neuroimaging Initiative
dc.contributor.authorAlzheimer’s Disease Repository Without Borders Investigators
dc.contributor.authorCALM Team
dc.contributor.authorCam-CAN
dc.contributor.authorCCNP
dc.contributor.authorCOBRE
dc.contributor.authorcVEDA
dc.contributor.authorENIGMA Developmental Brain Age Working Group
dc.contributor.authorDeveloping Human Connectome Project
dc.contributor.authorFinnBrain
dc.contributor.authorHarvard Aging Brain Study
dc.contributor.authorIMAGEN
dc.contributor.authorKNE96
dc.contributor.authorMayo Clinic Study of Aging
dc.contributor.authorNSPN
dc.contributor.authorPOND
dc.contributor.authorPREVENT-AD Research Group
dc.contributor.authorVETSA
dc.contributor.authorBullmore, ET
dc.contributor.authorAlexander-Bloch, AF
dc.date.accessioned2022-04-20T15:08:38Z
dc.date.available2022-04-20T15:08:38Z
dc.date.issued2022-04-06
dc.date.submitted2021-06-09
dc.identifier.issn0028-0836
dc.identifier.others41586-022-04554-y
dc.identifier.other4554
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/336270
dc.description.abstractOver the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data ( http://www.brainchart.io/ ). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones3, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectArticle
dc.subject/631/378/2611
dc.subject/631/378/1689
dc.subject/631/378/2649
dc.subject/631/378/2571
dc.subject/59/57
dc.subjectarticle
dc.titleBrain charts for the human lifespan.
dc.typeArticle
dc.date.updated2022-04-20T15:08:37Z
prism.endingPage533
prism.issueIdentifier7906
prism.publicationNameNature
prism.startingPage525
prism.volume604
dc.identifier.doi10.17863/CAM.83688
dcterms.dateAccepted2022-02-16
rioxxterms.versionofrecord10.1038/s41586-022-04554-y
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidWhite, Simon [0000-0001-8642-7037]
dc.contributor.orcidRowitch, David [0000-0002-0079-0060]
dc.identifier.eissn1476-4687
cam.issuedOnline2022-04-06


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