Distinct infant feeding type-specific plasma metabolites at age 3 months associate with body composition at 2 years.
Authors
van Beijsterveldt, Inge ALP
Myers, Pernille Neve
Snowden, Stuart G
Ong, Ken K
Brix, Susanne
Hokken-Koelega, Anita CS
Publication Date
2022-06Journal Title
Clin Nutr
ISSN
0261-5614
Publisher
Elsevier BV
Type
Article
This Version
AM
Metadata
Show full item recordCitation
van Beijsterveldt, I. A., Myers, P. N., Snowden, S. G., Ong, K. K., Brix, S., Hokken-Koelega, A. C., & Koulman, A. (2022). Distinct infant feeding type-specific plasma metabolites at age 3 months associate with body composition at 2 years.. Clin Nutr https://doi.org/10.1016/j.clnu.2022.04.015
Abstract
BACKGROUND & OBJECTIVES: Early life is a critical window for adiposity programming and metabolic profile may affect this programming. We investigated if plasma metabolites at age 3 months were associated with fat mass, fat free mass and abdominal subcutaneous and visceral fat outcomes at age 2 years in a cohort of healthy infants and if these associations were different between infants receiving exclusive breastfeeding (EBF) and those with exclusive formula feeding (EFF). METHODS: In 318 healthy term-born infants, we determined body composition by Dual Energy X-ray absorptiometry (DXA) and visceral fat by abdominal ultrasound at 2 age years. High-throughput metabolic profiling was performed on blood samples collected at age 3 months. Tertiles were generated for each body composition outcome and differences in plasma metabolite levels at age 3 months between infants with high and low body composition outcomes at age 2 years were evaluated in general, as well as separately in EBF- and EFF-infants. RESULTS: Distinct plasma metabolite variables identified at age 3 months were associated with body composition at 2 years. These metabolites included several classes of lyso-phospholipids. Associations between the metabolites at age 3 months and fat mass index, fat mass percentage, fat free mass index and visceral fat at 2 years were predominantly found in EBF-infants. CONCLUSION: Associations between plasma metabolite levels at age 3 months and high body fat mass at 2 years depend on infant feeding type. These findings contribute to our insight into the importance of infant feeding on adiposity programming in early life.
Sponsorship
This study was funded by the EU Commission to the JPI HDHL program ‘Call III Biomarkers’ for the project: BioFN - Biomarkers for Infant Fat Mass Development and Nutrition (Grant agreement No 696295), administrated in Denmark by Innovation Fund Denmark (grant number 4203-00005B), Netherlands Organisation for Health Research and Development (ZonMW) (grant number 529051013), in the UK by Biotechnology and Biological Sciences Research Council (BB/P028195/1) and Danone Nutricia Research, The Netherlands (to Rotterdam). AK is supported by the NIHR Cambridge Biomedical Research Centre (146281) and KKO is funded by the Medical Research Council (MC_UU_00006/2).
Funder references
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Biotechnology and Biological Sciences Research Council (BB/P028195/1)
MRC (MC_UU_00006/2)
Identifiers
External DOI: https://doi.org/10.1016/j.clnu.2022.04.015
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336282
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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