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dc.contributor.authorFulton, Timothy
dc.contributor.authorVerd, Berta
dc.contributor.authorSteventon, Benjamin
dc.date.accessioned2022-04-22T23:30:36Z
dc.date.available2022-04-22T23:30:36Z
dc.date.issued2022-04
dc.identifier.issn2054-5703
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/336387
dc.description.abstractThe mechanisms underpinning the formation of patterned cellular landscapes has been the subject of extensive study as a fundamental problem of developmental biology. In most cases, attention has been given to situations in which cell movements are negligible, allowing researchers to focus on the cell-extrinsic signalling mechanisms, and intrinsic gene regulatory interactions that lead to pattern emergence at the tissue level. However, in many scenarios during development, cells rapidly change their neighbour relationships in order to drive tissue morphogenesis, while also undergoing patterning. To draw attention to the ubiquity of this problem and propose methodologies that will accommodate morphogenesis into the study of pattern formation, we review the current approaches to studying pattern formation in both static and motile cellular environments. We then consider how the cell movements themselves may contribute to the generation of pattern, rather than hinder it, with both a species specific and evolutionary viewpoint.
dc.publisherThe Royal Society
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe unappreciated generative role of cell movements in pattern formation.
dc.typeArticle
dc.publisher.departmentDepartment of Genetics
dc.date.updated2022-04-22T13:47:42Z
prism.publicationNameR Soc Open Sci
dc.identifier.doi10.17863/CAM.83804
dcterms.dateAccepted2022-04-05
rioxxterms.versionofrecord10.1098/rsos.211293
rioxxterms.versionAM
dc.contributor.orcidVerd, Berta [0000-0001-9835-009X]
dc.contributor.orcidSteventon, Benjamin [0000-0001-7838-839X]
dc.identifier.eissn2054-5703
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (109408/Z/15/Z)
cam.issuedOnline2022-04-27
cam.orpheus.successWed May 25 11:13:42 BST 2022 - Embargo updated
cam.orpheus.counter1
cam.depositDate2022-04-22
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2022-04-27


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International