Modulation of hippocampal plasticity in learning and memory.
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Publication Date
2022-08Journal Title
Curr Opin Neurobiol
ISSN
0959-4388
Publisher
Elsevier BV
Type
Article
This Version
AM
Metadata
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Fuchsberger, T., & Paulsen, O. (2022). Modulation of hippocampal plasticity in learning and memory.. Curr Opin Neurobiol https://doi.org/10.1016/j.conb.2022.102558
Abstract
Synaptic plasticity plays a central role in the study of neural mechanisms of learning and memory. Plasticity rules are not invariant over time but are under neuromodulatory control, enabling behavioral states to influence memory formation. Neuromodulation controls synaptic plasticity at network level by directing information flow, at circuit level through changes in excitation/inhibition balance, and at synaptic level through modulation of intracellular signaling cascades. Although most research has focused on modulation of principal neurons, recent progress has uncovered important roles for interneurons in not only routing information, but also setting conditions for synaptic plasticity. Moreover, astrocytes have been shown to both gate and mediate plasticity. These additional mechanisms must be considered for a comprehensive mechanistic understanding of learning and memory.
Sponsorship
BBSRC
Embargo Lift Date
2023-06-02
Identifiers
External DOI: https://doi.org/10.1016/j.conb.2022.102558
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336488
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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