Circulating microRNAs for detecting germ cell tumours: a narrative review.
European Urology Focus
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Murray, M. Circulating microRNAs for detecting germ cell tumours: a narrative review.. European Urology Focus https://doi.org/10.17863/CAM.83938
Testicular germ cell tumours (GCTs) are the most common malignancy among young men. Management of GCTs relies on the serum tumour markers alpha-fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase, among other parameters. However, these tumour markers can only be detected at elevated levels in half of GCT patients. Circulating miR-371a-3p has emerged as a blood-based biomarker that can reliably detect macroscopic GCTs, aside from teratoma. In this article, we review the available literature, describe the currently used methodologies to measure circulating miR-371a-3p, and discuss the following clinical scenarios in which miR-371a-3p may impact practice in the future: 1) men with an inconclusive small testicular mass, 2) response monitoring during chemotherapy, 3) post-chemotherapy residual mass, and 4) follow-up after curative intent.
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This record's DOI: https://doi.org/10.17863/CAM.83938
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336518
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/