Circulating MicroRNAs for Detection of Germ Cell Tumours: A Narrative Review.
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Authors
Fankhauser, Christian D
Nuño, Michelle M
Murray, Matthew J
Frazier, Lindsay
Bagrodia, Aditya
Publication Date
2022-05Journal Title
Eur Urol Focus
ISSN
2405-4569
Publisher
Elsevier BV
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Fankhauser, C. D., Nuño, M. M., Murray, M. J., Frazier, L., & Bagrodia, A. (2022). Circulating MicroRNAs for Detection of Germ Cell Tumours: A Narrative Review.. Eur Urol Focus https://doi.org/10.1016/j.euf.2022.04.008
Abstract
Testicular germ cell tumours (GCTs) are the most common malignancy among young men. Management of GCTs relies on the serum tumour markers α-fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase, among other parameters. However, these tumour markers can only be detected at elevated levels in half of GCT patients. Circulating miR-371a-3p has emerged as a blood-based biomarker that can reliably detect macroscopic GCTs, aside from teratoma. Here we review the literature, describe the methodologies currently used to measure circulating miR-371a-3p, and discuss the following clinical scenarios in which miR-371a-3p may impact practice in the future: (1) men with an inconclusive small testicular mass; (2) response monitoring during chemotherapy; (3) postchemotherapy residual masses; and (4) follow-up after treatment with curative intent. PATIENT SUMMARY: We discuss the potential uses and promise, as well as current limitations, of a novel blood test that may improve care for men with testicular cancer.
Sponsorship
None
Embargo Lift Date
2023-05-07
Identifiers
External DOI: https://doi.org/10.1016/j.euf.2022.04.008
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336518
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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